ESR1 Antibody Isoform 1 (N-term) Blocking Peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Clone Names | 120215010 |
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Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
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Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
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Provided below are standard protocols that you may find useful for product applications.
Background
This gene encodes an estrogen receptor, a ligand-activatedtranscription factor composed of several domains important forhormone binding, DNA binding, and activation of transcription. Theprotein localizes to the nucleus where it may form a homodimer or aheterodimer with estrogen receptor 2. Estrogen and its receptorsare essential for sexual development and reproductive function, butalso play a role in other tissues such as bone. Estrogen receptorsare also involved in pathological processes including breastcancer, endometrial cancer, and osteoporosis. Alternative splicingresults in several transcript variants, which differ in their 5'UTRs and use different promoters.
References
Geradts, J., et al. Cancer Invest. 28(9):969-977(2010)Hayes, D.F., et al. Clin. Pharmacol. Ther. 88(5):626-629(2010)Lupien, M., et al. Genes Dev. 24(19):2219-2227(2010)Corbo, R.M., et al. J. Gerontol. A Biol. Sci. Med. Sci. (2010) In press :Kim, S., et al. Fertil. Steril. (2010) In press :
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