|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
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This gene encodes an estrogen receptor, a ligand-activatedtranscription factor composed of several domains important forhormone binding, DNA binding, and activation of transcription. Theprotein localizes to the nucleus where it may form a homodimer or aheterodimer with estrogen receptor 2. Estrogen and its receptorsare essential for sexual development and reproductive function, butalso play a role in other tissues such as bone. Estrogen receptorsare also involved in pathological processes including breastcancer, endometrial cancer, and osteoporosis. Alternative splicingresults in several transcript variants, which differ in their 5'UTRs and use different promoters.
Geradts, J., et al. Cancer Invest. 28(9):969-977(2010)Hayes, D.F., et al. Clin. Pharmacol. Ther. 88(5):626-629(2010)Lupien, M., et al. Genes Dev. 24(19):2219-2227(2010)Corbo, R.M., et al. J. Gerontol. A Biol. Sci. Med. Sci. (2010) In press :Kim, S., et al. Fertil. Steril. (2010) In press :
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