|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
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Provided below are standard protocols that you may find useful for product applications.
This gene encodes a member of the RING zinc finger proteinfamily found in striated muscle and iris. The product of this geneis localized to the Z-line and M-line lattices of myofibrils, wheretitin's N-terminal and C-terminal regions respectively bind to thesarcomere. In vitro binding studies have shown that this proteinalso binds directly to titin near the region of titin containingkinase activity. Another member of this protein family binds tomicrotubules. Since these family members can form heterodimers,this suggests that these proteins may serve as a link between titinkinase and microtubule-dependent signal pathways in muscle.
Conraads, V.M., et al. Basic Res. Cardiol. 105(2):219-226(2010)Mearini, G., et al. Cardiovasc. Res. 85(2):357-366(2010)Leger, B., et al. Muscle Nerve 40(1):69-78(2009)Mrosek, M., et al. Biochemistry 47(40):10722-10730(2008)Waddell, D.S., et al. Am. J. Physiol. Endocrinol. Metab. 295 (4), E785-E797 (2008) :
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