|Other Names||RNA-binding protein MEX3B, RING finger and KH domain-containing protein 3, RING finger protein 195, MEX3B, KIAA2009, RKHD3, RNF195|
|Target/Specificity||The synthetic peptide sequence used to generate the antibody AP1959a was selected from the N-term region of human RKHD3. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Synonyms||KIAA2009, RKHD3, RNF195|
|Function||RNA-binding protein. May be involved in post- transcriptional regulatory mechanisms.|
|Cellular Location||Nucleus. Cytoplasm. Cytoplasm, P-body. Cytoplasmic granule. Note=Predominantly expressed in the cytoplasm and shuttles between the cytoplasm and the nucleus through the CRM1 export pathway. Localization to P-bodies is dependent on 14-3-3|
|Tissue Location||Highest levels found in fetal brain and testis. Detected in the adult intestinal epithelium, specifically in goblet cell at protein level.|
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Provided below are standard protocols that you may find useful for product applications.
RKHD3, also known as MEX3B is a member of a family of four homologous human MEX3 proteins each containing two heterogeneous nuclear ribonucleoprotein K homology (KH) domains and one carboxy-terminal RING finger module. MEX3 proteins, including RKHD3, are phosphoproteins that bind RNA through their KH domains and shuttle between the nucleus and the cytoplasm via the CRM1-dependent export pathway. MEX3A and MEX3B, but not MEX3C,colocalize with both the hDcp1a decapping factor and Argonaute (Ago) proteins in processing bodies (P bodies), recently characterized as centers of mRNA turnover. MEX3 proteins are a novel family of evolutionarily conserved RNA-binding proteins, differentially recruited to P bodies and potentially involved in post-transcriptional regulatory mechanisms.
Buchet-Poyau,K., Nucleic Acids Res. 35 (4), 1289-1300 (2007)
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