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CCR5 Antibody(Center) Blocking peptide

Synthetic peptide

Product Information
Primary Accession P51681
Clone Names 90713033
Peptide ID 90713033
Additional Information
Gene ID 1234
Other Names C-C chemokine receptor type 5, C-C CKR-5, CC-CKR-5, CCR-5, CCR5, CHEMR13, HIV-1 fusion coreceptor, CD195, CCR5, CMKBR5
Format Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name CCR5
Synonyms CMKBR5
Function Receptor for a number of inflammatory CC-chemokines including MIP-1-alpha, MIP-1-beta and RANTES and subsequently transduces a signal by increasing the intracellular calcium ion level. May play a role in the control of granulocytic lineage proliferation or differentiation. Acts as a coreceptor (CD4 being the primary receptor) for HIV-1 R5 isolates.
Cellular Location Cell membrane; Multi-pass membrane protein
Tissue Location Highly expressed in spleen, thymus, in the myeloid cell line THP-1, in the promyeloblastic cell line KG-1a and on CD4+ and CD8+ T-cells. Medium levels in peripheral blood leukocytes and in small intestine. Low levels in ovary and lung
Research Areas
Citations (0)

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This gene encodes a member of the beta chemokine receptorfamily, which is predicted to be a seven transmembrane proteinsimilar to G protein-coupled receptors. This protein is expressedby T cells and macrophages, and is known to be an importantco-receptor for macrophage-tropic virus, including HIV, to enterhost cells. Defective alleles of this gene have been associatedwith the HIV infection resistance. The ligands of this receptorinclude monocyte chemoattractant protein 2 (MCP-2), macrophageinflammatory protein 1 alpha (MIP-1 alpha), macrophage inflammatoryprotein 1 beta (MIP-1 beta) and regulated on activation normal Texpressed and secreted protein (RANTES). Expression of this genewas also detected in a promyeloblastic cell line, suggesting thatthis protein may play a role in granulocyte lineage proliferationand differentiation. This gene is located at the chemokine receptorgene cluster region. Two transcript variants encoding the sameprotein have been found for this gene.


Gerard, H.C., et al. Am. J. Med. Sci. 340(6):448-451(2010)Hammad, M.M., et al. J. Biol. Chem. 285(45):34653-34664(2010)Martens, H.A., et al. J. Rheumatol. 37(11):2226-2231(2010)Weng, C.J., et al. Oral Oncol. 46(10):767-772(2010)Mamtani, M., et al. PLoS ONE 5 (7), E11458 (2010) :

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$ 80.00
Cat# BP19617c
(40 western blots)
Availability: In Stock
Bulk Size
Seasonal Special on Bulk Order
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