|Other Names||C-C chemokine receptor type 5, C-C CKR-5, CC-CKR-5, CCR-5, CCR5, CHEMR13, HIV-1 fusion coreceptor, CD195, CCR5, CMKBR5|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Receptor for a number of inflammatory CC-chemokines including MIP-1-alpha, MIP-1-beta and RANTES and subsequently transduces a signal by increasing the intracellular calcium ion level. May play a role in the control of granulocytic lineage proliferation or differentiation. Acts as a coreceptor (CD4 being the primary receptor) for HIV-1 R5 isolates.|
|Cellular Location||Cell membrane; Multi-pass membrane protein|
|Tissue Location||Highly expressed in spleen, thymus, in the myeloid cell line THP-1, in the promyeloblastic cell line KG-1a and on CD4+ and CD8+ T-cells. Medium levels in peripheral blood leukocytes and in small intestine. Low levels in ovary and lung|
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This gene encodes a member of the beta chemokine receptorfamily, which is predicted to be a seven transmembrane proteinsimilar to G protein-coupled receptors. This protein is expressedby T cells and macrophages, and is known to be an importantco-receptor for macrophage-tropic virus, including HIV, to enterhost cells. Defective alleles of this gene have been associatedwith the HIV infection resistance. The ligands of this receptorinclude monocyte chemoattractant protein 2 (MCP-2), macrophageinflammatory protein 1 alpha (MIP-1 alpha), macrophage inflammatoryprotein 1 beta (MIP-1 beta) and regulated on activation normal Texpressed and secreted protein (RANTES). Expression of this genewas also detected in a promyeloblastic cell line, suggesting thatthis protein may play a role in granulocyte lineage proliferationand differentiation. This gene is located at the chemokine receptorgene cluster region. Two transcript variants encoding the sameprotein have been found for this gene.
Gerard, H.C., et al. Am. J. Med. Sci. 340(6):448-451(2010)Hammad, M.M., et al. J. Biol. Chem. 285(45):34653-34664(2010)Martens, H.A., et al. J. Rheumatol. 37(11):2226-2231(2010)Weng, C.J., et al. Oral Oncol. 46(10):767-772(2010)Mamtani, M., et al. PLoS ONE 5 (7), E11458 (2010) :
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