|Other Names||Myosin regulatory light chain 12B, MLC-2A, MLC-2, Myosin regulatory light chain 2-B, smooth muscle isoform, Myosin regulatory light chain 20 kDa, MLC20, Myosin regulatory light chain MRLC2, SHUJUN-1, MYL12B, MRLC2, MYLC2B|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Myosin regulatory subunit that plays an important role in regulation of both smooth muscle and nonmuscle cell contractile activity via its phosphorylation. Phosphorylation triggers actin polymerization in vascular smooth muscle. Implicated in cytokinesis, receptor capping, and cell locomotion (By similarity).|
|Tissue Location||Ubiquitously expressed in various hematopoietic cells.|
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Provided below are standard protocols that you may find useful for product applications.
The activity of nonmuscle myosin II (see MYH9; MIM 160775)is regulated by phosphorylation of a regulatory light chain, suchas MRLC2. This phosphorylation results in higher MgATPase activityand the assembly of myosin II filaments (Iwasaki et al., 2001[PubMed 11942626]).
Martins-de-Souza, D., et al. Eur Arch Psychiatry Clin Neurosci 259(3):151-163(2009)Umeda, D., et al. Biochem. Biophys. Res. Commun. 333(2):628-635(2005)Li, T.B., et al. Acta Biochim. Biophys. Sin. (Shanghai) 36(6):412-418(2004)Webb, R.C. Adv Physiol Educ 27 (1-4), 201-206 (2003) :Iwasaki, T., et al. Cell Struct. Funct. 26(6):677-683(2001)
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