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MEFV Antibody(Center) Blocking peptide

Synthetic peptide

Product Information
Primary Accession O15553
Clone Names 90625009
Peptide ID 90625009
Additional Information
Gene ID 4210
Other Names Pyrin, Marenostrin, MEFV, MEF
Format Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Synonyms MEF
Function Involved in innate immunity and the inflammatory response. Interacts with several components of the inflammasome complex, a large oligomeric structure which recruits and activates CASP1 and ultimately induces maturation of cytokines such as IL1B. However, the exact role of MEFV in the inflammatory pathway is uncertain as contradictory effects on IL1B processing have been reported in different experimental systems. Has been shown to activate IL1B production (PubMed:16037825). Has also been shown to inhibit IL1B production (PubMed:16785446, PubMed:17431422). Also required for PSTPIP1-induced PYCARD oligomerization and for formation of pyroptosomes, large supramolecular structures composed of oligomerized PYCARD dimers which form prior to inflammatory apoptosis. Can reduce PYCARD-induced apoptosis. Recruits PSTPIP1 to pyroptosomes, and required for PSTPIP1 oligomerization.
Cellular Location Isoform 1: Cytoplasm, cytoskeleton. Cell projection, ruffle. Cell projection, lamellipodium. Nucleus Note=Associated with microtubules and with the filamentous actin of perinuclear filaments and peripheral lamellar ruffles. In pre- apoptotic cells, colocalizes with PYCARD/ASC in large specks (pyroptosomes). In migrating monocytes, strongly polarized at the leading edge of the cell where it colocalizes with polymerizing actin and PYCARD/ASC
Tissue Location Expressed in peripheral blood leukocytes, particularly in mature granulocytes and to a lesser extent in monocytes but not in lymphocytes. Detected in spleen, lung and muscle, probably as a result of leukocyte infiltration in these tissues. Not expressed in thymus, prostate, testis, ovary, small intestine, colon, heart, brain, placenta, liver, kidney, pancreas Expression detected in several myeloid leukemic, colon cancer, and prostate cancer cell lines.
Research Areas
Citations (0)

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This gene encodes a protein, also known as pyrin ormarenostrin, that is an important modulator of innate immunity.Mutations in this gene are associated with Mediterranean fever, ahereditary periodic fever syndrome.


Cosan, F., et al. Arthritis Rheum. 62(11):3232-3236(2010)Shimada, M., et al. Hum. Genet. 128(4):433-441(2010)Bailey, S.D., et al. Diabetes Care 33(10):2250-2253(2010)He, X., et al. Pediatr. Nephrol. 25(10):2077-2082(2010)Simsek, I., et al. Clin. Rheumatol. (2010) In press :

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$ 80.00
Cat# BP19672c
(40 western blots)
Availability: In Stock
Bulk Size
Seasonal Special on Bulk Order
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