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LGALS7 Blocking Peptide(Center)
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
| Primary Accession | P47929 |
|---|---|
| Other Accession | NP_001035972.1, NP_002298.1 |
| Gene ID | 3963;653499 |
|---|---|
| Other Names | Galectin-7, Gal-7, HKL-14, PI7, p53-induced gene 1 protein, LGALS7, PIG1 |
| Target/Specificity | The synthetic peptide sequence is selected from aa 69-82 of HUMAN LGALS7 |
| Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
| Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
| Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
| Name | LGALS7 |
|---|---|
| Synonyms | PIG1 |
| Function | Could be involved in cell-cell and/or cell-matrix interactions necessary for normal growth control. Pro-apoptotic protein that functions intracellularly upstream of JNK activation and cytochrome c release. |
| Cellular Location | Cytoplasm. Nucleus. Secreted. Note=May be secreted by a non-classical secretory pathway |
| Tissue Location | Mainly expressed in stratified squamous epithelium. |
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Provided below are standard protocols that you may find useful for product applications.
Background
The galectins are a family of beta-galactoside-binding proteins implicated in modulating cell-cell and cell-matrix interactions. Differential and in situ hybridization studies indicate that this lectin is specifically expressed in keratinocytes and found mainly in stratified squamous epithelium. A duplicate copy of this gene (GeneID:653499) is found adjacent to, but on the opposite strand on chromosome 19.
References
Demers, M., et al. Am. J. Pathol. 176(6):3023-3031(2010)
Zhu, X., et al. BMC Cancer 10, 290 (2010) :
Park, J.E., et al. Oncol. Rep. 22(6):1373-1379(2009)
Demers, M., et al. Biochem. Biophys. Res. Commun. 387(3):425-429(2009)
Saussez, S., et al. Int. J. Oncol. 34(2):433-439(2009)
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