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>   home   >   Products   >   Peptides   >   Blocking Peptides   >   VPS25 Blocking Peptide(C-term)   

VPS25 Blocking Peptide(C-term)

Synthetic peptide

Product Information
Primary Accession Q9BRG1
Other Accession Q5E9A6, NP_115729.1
Additional Information
Gene ID 84313
Other Names Vacuolar protein-sorting-associated protein 25, hVps25, Dermal papilla-derived protein 9, ELL-associated protein of 20 kDa, ESCRT-II complex subunit VPS25, VPS25, DERP9, EAP20
Target/Specificity The synthetic peptide sequence is selected from aa 131-144 of HUMAN VPS25
Format Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name VPS25
Synonyms DERP9, EAP20
Function Component of the ESCRT-II complex (endosomal sorting complex required for transport II), which is required for multivesicular body (MVB) formation and sorting of endosomal cargo proteins into MVBs. The MVB pathway mediates delivery of transmembrane proteins into the lumen of the lysosome for degradation. The ESCRT-II complex is probably involved in the recruitment of the ESCRT-III complex. The ESCRT-II complex may also play a role in transcription regulation, possibly via its interaction with ELL. The ESCRT-II complex may be involved in facilitating the budding of certain RNA viruses.
Cellular Location Cytoplasm. Endosome membrane. Nucleus, nucleoplasm. Note=Distributes diffusely throughout the cytoplasm and nucleoplasm, but exhibits a punctate distribution on coexpression with CHMP6
Tissue Location Expressed at the mRNA level in kidney, liver, pancreas, and placenta. Lower levels of expression are found in heart, skeletal muscle, brain and lung
Research Areas
Citations (0)

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VPS25, VPS36 (MIM 610903), and SNF8 (MIM 610904) form ESCRT-II (endosomal sorting complex required for transport II), a complex involved in endocytosis of ubiquitinated membrane proteins. VPS25, VPS36, and SNF8 are also associated in a multiprotein complex with RNA polymerase II elongation factor (ELL; MIM 600284) (Slagsvold et al., 2005 [PubMed 15755741]; Kamura et al., 2001 [PubMed 11278625]).


Bailey, S.D., et al. Diabetes Care 33(10):2250-2253(2010)
Talmud, P.J., et al. Am. J. Hum. Genet. 85(5):628-642(2009)
Im, Y.J., et al. Dev. Cell 17(2):234-243(2009)
Lamesch, P., et al. Genomics 89(3):307-315(2007)
Bowers, K., et al. J. Biol. Chem. 281(8):5094-5105(2006)

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$ 80.00
$ 99.00
Cat# BP19683b
(40 western blots)
Availability: 2 weeks
Bulk Size
Seasonal Special on Bulk Order
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