|Other Names||Sentrin-specific protease 1, SUMO-1 protease 2, SuPr-2, Sentrin/SUMO-specific protease SENP1, Senp1, Supr2|
|Target/Specificity||The synthetic peptide sequence is selected from aa 277-289 of MOUSE Senp1|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Protease that catalyzes two essential functions in the SUMO pathway: processing of full-length SUMO1, SUMO2 and SUMO3 to their mature forms and deconjugation of SUMO1, SUMO2 and SUMO3 from targeted proteins. Deconjugates SUMO1 from HIPK2. Deconjugates SUMO1 from HDAC1 and BHLHE40/DEC1, which decreases its transcriptional repression activity. Deconjugates SUMO1 from CLOCK, which decreases its transcriptional activation activity. Deconjugates SUMO2 from MTA1.|
|Cellular Location||Nucleus. Cytoplasm. Note=Shuttles between cytoplasm and nucleus|
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Provided below are standard protocols that you may find useful for product applications.
Protease that catalyzes two essential functions in the SUMO pathway: processing of full-length SUMO1, SUMO2 and SUMO3 to their mature forms and deconjugation of SUMO1, SUMO2 and SUMO3 from targeted proteins. Deconjugates SUMO1 from HIPK2. Deconjugates SUMO1 from HDAC1, which decreases its transcriptional repression activity.
Bawa-Khalfe, T., et al. J. Biol. Chem. 285(33):25859-25866(2010)
Yu, L., et al. J. Exp. Med. 207(6):1183-1195(2010)
Sharma, P., et al. J. Cell. Sci. 123 (PT 8), 1227-1234 (2010) :
Li, X., et al. Cell Death Differ. 15(4):739-750(2008)
Cheng, J., et al. Cell 131(3):584-595(2007)
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