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Mouse Senp1 Blocking Peptide(Center)

Synthetic peptide

     
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Product Information
Primary Accession P59110
Other Accession NP_659100.1
Additional Information
Gene ID 223870
Other Names Sentrin-specific protease 1, SUMO-1 protease 2, SuPr-2, Sentrin/SUMO-specific protease SENP1, Senp1, Supr2
Target/Specificity The synthetic peptide sequence is selected from aa 277-289 of MOUSE Senp1
Format Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name Senp1
Synonyms Supr2
Function Protease that catalyzes two essential functions in the SUMO pathway: processing of full-length SUMO1, SUMO2 and SUMO3 to their mature forms and deconjugation of SUMO1, SUMO2 and SUMO3 from targeted proteins. Deconjugates SUMO1 from HIPK2. Deconjugates SUMO1 from HDAC1 and BHLHE40/DEC1, which decreases its transcriptional repression activity. Deconjugates SUMO1 from CLOCK, which decreases its transcriptional activation activity. Deconjugates SUMO2 from MTA1. Desumoylates CCAR2 which decreases its interaction with SIRT1 (By similarity).
Cellular Location Nucleus {ECO:0000250|UniProtKB:Q9P0U3}. Cytoplasm. Note=Shuttles between cytoplasm and nucleus.
Research Areas
Citations (0)

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Background

Protease that catalyzes two essential functions in the SUMO pathway: processing of full-length SUMO1, SUMO2 and SUMO3 to their mature forms and deconjugation of SUMO1, SUMO2 and SUMO3 from targeted proteins. Deconjugates SUMO1 from HIPK2. Deconjugates SUMO1 from HDAC1, which decreases its transcriptional repression activity.

References

Bawa-Khalfe, T., et al. J. Biol. Chem. 285(33):25859-25866(2010)
Yu, L., et al. J. Exp. Med. 207(6):1183-1195(2010)
Sharma, P., et al. J. Cell. Sci. 123 (PT 8), 1227-1234 (2010) :
Li, X., et al. Cell Death Differ. 15(4):739-750(2008)
Cheng, J., et al. Cell 131(3):584-595(2007)

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$ 80.00
Cat# BP19695c
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