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ASCL1 Blocking Peptide(N-term)

Synthetic peptide

Product Information
Primary Accession P50553
Other Accession NP_004307.2
Additional Information
Gene ID 429
Other Names Achaete-scute homolog 1, ASH-1, hASH1, Class A basic helix-loop-helix protein 46, bHLHa46, ASCL1, ASH1, BHLHA46, HASH1
Target/Specificity The synthetic peptide sequence is selected from aa 78-90 of HUMAN ASCL1
Format Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name ASCL1
Synonyms ASH1, BHLHA46, HASH1
Function Transcription factor that controls transcriptional expression of its target genes by binding to the E box (5'-CANNTG- 3'). Plays a role at early stages of development of specific neural lineages in most regions of the CNS, and of several lineages in the PNS. Acts synergistically with FOXN4 to specify the identity of V2b neurons rather than V2a from bipotential p2 progenitors during spinal cord neurogenesis, probably through DLL4-NOTCH signaling activation. Essential for the generation of olfactory and autonomic neurons (By similarity).
Cellular Location Nucleus.
Research Areas
Citations (0)

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This gene encodes a member of the basic helix-loop-helix (BHLH) family of transcription factors. The protein activates transcription by binding to the E box (5'-CANNTG-3'). Dimerization with other BHLH proteins is required for efficient DNA binding. This protein plays a role in the neuronal commitment and differentiation and in the generation of olfactory and autonomic neurons. Mutations in this gene may contribute to the congenital central hypoventilation syndrome (CCHS) phenotype in rare cases.


Phi, J.H., et al. J Neurosurg Pediatr 5(6):608-614(2010)
McGaughey, D.M., et al. Genomics 95(6):363-369(2010)
Li, F., et al. Zhongguo Fei Ai Za Zhi 13(4):317-321(2010)
Deng, H., et al. Biochem. Biophys. Res. Commun. 392(4):548-550(2010)
Improgo, M.R., et al. Mol. Cancer Res. 8(2):194-203(2010)

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$ 80.00
$ 99.00
Cat# BP19731a
(40 western blots)
Availability: 2 weeks
Bulk Size
Seasonal Special on Bulk Order
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