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CLSTN2 Blocking Peptide(Center)
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
| Primary Accession | Q9H4D0 |
|---|---|
| Other Accession | NP_071414.2 |
| Gene ID | 64084 |
|---|---|
| Other Names | Calsyntenin-2, Alcadein-gamma, Alc-gamma, CLSTN2, CS2 |
| Target/Specificity | The synthetic peptide sequence is selected from aa 758-770 of HUMAN CLSTN2 |
| Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
| Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
| Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
| Name | CLSTN2 (HGNC:17448) |
|---|---|
| Synonyms | CS2 |
| Function | Postsynaptic adhesion molecule that binds to presynaptic neurexins to mediate synapse formation, and which is involved in learning and memory (By similarity). Promotes synapse development by acting as a cell adhesion molecule at the postsynaptic membrane, which associates with neurexin-alpha at the presynaptic membrane (By similarity). |
| Cellular Location | Postsynaptic cell membrane {ECO:0000250|UniProtKB:Q9ER65}; Single-pass type I membrane protein. Endoplasmic reticulum membrane {ECO:0000250|UniProtKB:Q9ER65}; Single-pass type I membrane protein. Golgi apparatus membrane {ECO:0000250|UniProtKB:Q9ER65}; Single-pass type I membrane protein. Cell projection, dendrite {ECO:0000250|UniProtKB:Q9ER65}. Note=Most prominent in the postsynaptic specializations of asymmetric (type I) synapses with both axodendritic and axospinous localization {ECO:0000250|UniProtKB:Q9ER65} |
| Tissue Location | Restricted to the brain. |
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
Background
CLSTN2 may modulate calcium-mediated postsynaptic signals (By similarity).
References
Rose, J.E., et al. Mol. Med. 16 (7-8), 247-253 (2010) :
Preuschhof, C., et al. Neuropsychologia 48(2):402-408(2010)
Zhang, H., et al. Neuropsychopharmacology 34(12):2508-2516(2009)
Henckaerts, L., et al. Clin. Gastroenterol. Hepatol. 7(9):972-980(2009)
Jacobsen, L.K., et al. Biol. Psychiatry 65(8):671-679(2009)
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