|Other Accession||Q9QZV9, Q2KIW0, NP_037380.1|
|Other Names||NTF2-related export protein 1, Protein p15, NXT1|
|Target/Specificity||The synthetic peptide sequence is selected from aa 100-111 of HUMAN NXT1|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Stimulator of protein export for NES-containing proteins. Also plays a role in the nuclear export of U1 snRNA, tRNA, and mRNA. The NXF1-NXT1 heterodimer is involved in the export of HSP70 mRNA in conjunction with ALYREF/THOC4 and THOC5.|
|Cellular Location||Nucleus. Nucleus speckle. Cytoplasm. Note=Shuttles between the nucleus and the cytoplasm|
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The protein encoded by this gene is located in the nuclear envelope. It has protein similarity to nuclear transport factor 2. This protein functions as a nuclear export factor in both RAN (Ras-related nuclear protein)- and CRM1 (required for chromosome region maintenance)-dependent pathways. It is found to stimulate the export of U1 snRNA in RAN- and CRM1-dependent pathways and the export of tRNA and mRNA in a CRM1-independent pathway. The encoded protein heterodimerizes with Tap protein and may regulate the ability of Tap protein to mediate nuclear mRNA export. The use of alternate polyadenylation sites has been found for this gene.
Venkatesan, K., et al. Nat. Methods 6(1):83-90(2009)
Forler, D., et al. Nat. Biotechnol. 21(1):89-92(2003)
Katahira, J., et al. J. Biol. Chem. 277(11):9242-9246(2002)
Wiegand, H.L., et al. Mol. Cell. Biol. 22(1):245-256(2002)
Deloukas, P., et al. Nature 414(6866):865-871(2001)
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