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UBE2R2 Blocking Peptide (Center)
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
| Primary Accession | Q712K3 |
|---|---|
| Other Accession | Q29503, Q6ZWZ2, NP_060281.2 |
| Gene ID | 54926 |
|---|---|
| Other Names | Ubiquitin-conjugating enzyme E2 R2, Ubiquitin carrier protein R2, Ubiquitin-conjugating enzyme E2-CDC34B, Ubiquitin-protein ligase R2, UBE2R2, CDC34B, UBC3B |
| Target/Specificity | The synthetic peptide sequence is selected from aa 156-169 of HUMAN UBE2R2 |
| Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
| Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
| Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
| Name | UBE2R2 |
|---|---|
| Synonyms | CDC34B, UBC3B |
| Function | Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. In vitro catalyzes monoubiquitination and 'Lys-48'-linked polyubiquitination. May be involved in degradation of katenin. |
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Provided below are standard protocols that you may find useful for product applications.
Background
Protein kinase CK2 is a ubiquitous and pleiotropic Ser/Thr protein kinase involved in cell growth and transformation. This gene encodes a protein similar to the E2 ubiquitin conjugating enzyme UBC3/CDC34. Studies suggest that CK2-dependent phosphorylation of this ubiquitin-conjugating enzyme functions by regulating beta-TrCP substrate recognition and induces its interaction with beta-TrCP, enhancing beta-catenin degradation.
References
Rose, J.E., et al. Mol. Med. 16 (7-8), 247-253 (2010) :
Yoshida, T., et al. Int. J. Mol. Med. 25(4):649-656(2010)
Oguri, M., et al. Am. J. Hypertens. 23(1):70-77(2010)
Ferreira, M.A., et al. Nat. Genet. 40(9):1056-1058(2008)
Humphray, S.J., et al. Nature 429(6990):369-374(2004)
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