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Mouse Slc5a8 Blocking Peptide (C-term)

Synthetic peptide

     
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Product Information
Primary Accession Q8BYF6
Other Accession NP_663398.2
Additional Information
Gene ID 216225
Other Names Sodium-coupled monocarboxylate transporter 1, Electrogenic sodium monocarboxylate cotransporter, Solute carrier family 5 member 8, Slc5a8 {ECO:0000312|MGI:MGI:2384916}
Target/Specificity The synthetic peptide sequence is selected from aa 563-574 of MOUSE Slc5a8
Format Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name Slc5a8 {ECO:0000312|MGI:MGI:2384916}
Function Acts as an electrogenic sodium (Na(+)) and chloride (Cl-)-dependent sodium-coupled solute transporter, including transport of monocarboxylates (short-chain fatty acids including L-lactate, D-lactate, pyruvate, acetate, propionate, valerate and butyrate), lactate, mocarboxylate drugs (nicotinate, benzoate, salicylate and 5-aminosalicylate) and ketone bodies (beta-D- hydroxybutyrate, acetoacetate and alpha-ketoisocaproate), with a Na(+):substrate stoichiometry of between 4:1 and 2:1. Catalyzes passive carrier mediated diffusion of iodide. Mediates iodide transport from the thyrocyte into the colloid lumen through the apical membrane. May be responsible for the absorption of D- lactate and monocarboxylate drugs from the intestinal tract. May play a critical role in the entry of L-lactate and ketone bodies into neurons by a process driven by an electrochemical Na(+) gradient and hence contribute to the maintenance of the energy status and function of neurons.
Cellular Location Membrane; Multi-pass membrane protein. Apical cell membrane; Multi-pass membrane protein Note=Restricted to the apical cell membrane of enterocytes
Tissue Location Expressed in brain, colon, kidney and in the ileum and jejunum of small intestine. In the kidney, expression occurred in the proximal tubule and the loop of Henle, being restricted to tubular epithelial cells in both the cortex and the medulla. In the colon, predominantly expressed in the distal half of the large bowel and in the most terminal ileum. Localized selectively in the luminal surface of crypts in the large intestine and to the brush border in the middle parts of crypts in the cecum. In the brain, expression was seen throughout, exclusively in neurons, including the cortex, hippocampus, cerebellum and pituitary gland (at protein level). Expression is reduced in oligodendrogliomas.
Research Areas
Citations (0)

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Background

Acts as an electrogenic sodium (Na(+)) and chloride (Cl-)-dependent sodium-coupled solute transporter, including transport of monocarboxylates (short-chain fatty acids including L-lactate, D-lactate, pyruvate, acetate, propionate, valerate and butyrate), lactate, mocarboxylate drugs (nicotinate, benzoate, salicylate and 5-aminosalicylate) and ketone bodies (beta-D-hydroxybutyrate, acetoacetate and alpha-ketoisocaproate), with a Na(+):substrate stoichiometry of between 4:1 and 2:1. Catalyzes passive carrier mediated diffusion of iodide. Mediates iodide transport from the thyrocyte into the colloid lumen through the apical membrane. May be responsible for the absorption of D-lactate and monocarboxylate drugs from the intestinal tract. May play a critical role in the entry of L-lactate and ketone bodies into neurons by a process driven by an electrochemical Na(+) gradient and hence contribute to the maintenance of the energy status and function of neurons.

References

Borthakur, A., et al. Am. J. Physiol. Gastrointest. Liver Physiol. 299 (4), G928-G934 (2010) :
Singh, N., et al. J. Biol. Chem. 285(36):27601-27608(2010)
Becker, H.M., et al. Am. J. Physiol. Renal Physiol. 299 (1), F141-F154 (2010) :
Miyauchi, S., et al. Biochim. Biophys. Acta 1798(6):1164-1171(2010)
Cresci, G.A., et al. J. Gastrointest. Surg. 14(3):449-461(2010)

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Cat# BP19791b
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