|Other Names||Insulin receptor-related protein, IRR, IR-related receptor, Insulin receptor-related protein alpha chain, Insulin receptor-related protein beta chain, INSRR, IRR|
|Target/Specificity||The synthetic peptide sequence is selected from aa 759-773 of HUMAN INSRR|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Receptor with tyrosine-protein kinase activity. Functions as a pH sensing receptor which is activated by increased extracellular pH. Activates an intracellular signaling pathway that involves IRS1 and AKT1/PKB.|
|Cellular Location||Membrane; Single-pass type I membrane protein|
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Provided below are standard protocols that you may find useful for product applications.
This receptor probably binds an insulin related protein and has a tyrosine-protein kinase activity. It phosphorylates the insulin receptor substrates IRS-1 and IRS-2.
Lu, Y., et al. J. Lipid Res. 49(12):2582-2589(2008)
Dissen, G.A., et al. Endocrinology 147(1):155-165(2006)
Klammt, J., et al. Biochem. Biophys. Res. Commun. 327(2):557-564(2005)
Weber, A., et al. Clin. Cancer Res. 9(15):5683-5692(2003)
Whitmore, T.E., et al. Cytogenet. Cell Genet. 87 (1-2), 93-94 (1999) :
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