|Other Accession||Q19AZ8, NP_000497.1|
|Other Names||Prothrombin, Coagulation factor II, Activation peptide fragment 1, Activation peptide fragment 2, Thrombin light chain, Thrombin heavy chain, F2|
|Target/Specificity||The synthetic peptide sequence is selected from aa 426-440 of HUMAN F2|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Thrombin, which cleaves bonds after Arg and Lys, converts fibrinogen to fibrin and activates factors V, VII, VIII, XIII, and, in complex with thrombomodulin, protein C. Functions in blood homeostasis, inflammation and wound healing.|
|Cellular Location||Secreted, extracellular space.|
|Tissue Location||Expressed by the liver and secreted in plasma.|
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Provided below are standard protocols that you may find useful for product applications.
Coagulation factor II is proteolytically cleaved to form thrombin in the first step of the coagulation cascade which ultimately results in the stemming of blood loss. F2 also plays a role in maintaining vascular integrity during development and postnatal life. Mutations in F2 leads to various forms of thrombosis and dysprothrombinemia.
Simchen, M.J., et al. Eur. J. Obstet. Gynecol. Reprod. Biol. 153(2):160-164(2010)
Evagelidou, E.N., et al. Diabetes Care 33(11):2468-2470(2010)
Ikejiri, M., et al. Int. J. Hematol. 92(2):302-305(2010)
Fusconi, M., et al. Audiol. Neurootol. 16(3):185-190(2010)
Jacobsen, A.F., et al. J. Thromb. Haemost. (2010) In press :
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