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TXNIP Blocking Peptide(N-term)

Synthetic peptide

     
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Product Information
Primary Accession Q9H3M7
Other Accession Q5M7W1, Q8BG60, NP_006463.3
Additional Information
Gene ID 10628
Other Names Thioredoxin-interacting protein, Thioredoxin-binding protein 2, Vitamin D3 up-regulated protein 1, TXNIP, VDUP1
Target/Specificity The synthetic peptide sequence is selected from aa 14-27 of HUMAN TXNIP
Format Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name TXNIP
Synonyms VDUP1
Function May act as an oxidative stress mediator by inhibiting thioredoxin activity or by limiting its bioavailability. Interacts with COPS5 and restores COPS5-induced suppression of CDKN1B stability, blocking the COPS5-mediated translocation of CDKN1B from the nucleus to the cytoplasm. Functions as a transcriptional repressor, possibly by acting as a bridge molecule between transcription factors and corepressor complexes, and over- expression will induce G0/G1 cell cycle arrest. Required for the maturation of natural killer cells. Acts as a suppressor of tumor cell growth. Inhibits the proteasomal degradation of DDIT4, and thereby contributes to the inhibition of the mammalian target of rapamycin complex 1 (mTORC1).
Cellular Location Cytoplasm.
Research Areas
Citations (0)

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Background

TXNIP may act as an oxidative stress mediator by inhibiting thioredoxin activity or by limiting its bioavailability. Interacts with COPS5 and restores COPS5-induced suppression of CDKN1B stability, blocking the COPS5-mediated translocation of CDKN1B from the nucleus to the cytoplasm. Functions as a transcriptional repressor, possibly by acting as a bridge molecule between transcription factors and corepressor complexes, and over-expression will induce G0/G1 cell cycle arrest. Required for the maturation of natural killer cells.

References

Zhuo de, X., et al. J. Biol. Chem. 285(41):31491-31501(2010)
Kwon, H.J., et al. J. Immunol. 185(7):3980-3989(2010)
Bailey, S.D., et al. Diabetes Care 33(10):2250-2253(2010)
Yu, F.X., et al. J. Biol. Chem. 285(33):25822-25830(2010)
Cadenas, C., et al. Breast Cancer Res. 12 (3), R44 (2010) :

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$ 80.00
$ 99.00
Cat# BP19855a
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