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NR2E1 Blocking Peptide (Center)

Synthetic peptide

Product Information
Primary Accession Q9Y466
Other Accession P70052, Q64104, Q91379, NP_003260.1
Additional Information
Gene ID 7101
Other Names Nuclear receptor subfamily 2 group E member 1, Nuclear receptor TLX, Protein tailless homolog, Tll, hTll, NR2E1, TLX
Target/Specificity The synthetic peptide sequence is selected from aa 90-102 of HUMAN NR2E1
Format Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name NR2E1
Synonyms TLX
Function Orphan receptor that binds DNA as a monomer to hormone response elements (HRE) containing an extended core motif half- site sequence 5'-AAGGTCA-3' in which the 5' flanking nucleotides participate in determining receptor specificity (By similarity). May be required to pattern anterior brain differentiation. Involved in the regulation of retinal development and essential for vision. During retinogenesis, regulates PTEN-Cyclin D expression via binding to the promoter region of PTEN and suppressing its activity (By similarity). May be involved in retinoic acic receptor (RAR) regulation in retinal cells.
Cellular Location Nucleus {ECO:0000255|PROSITE- ProRule:PRU00407}
Tissue Location Brain specific. Present in all brain sections tested, highest levels in the caudate nucleus and hippocampus, weakest levels in the thalamus.
Research Areas
Citations (0)

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Orphan receptor that binds DNA as a monomer to hormone response elements (HRE) containing an extended core motif half-site sequence 5'-AAGGTCA-3' in which the 5' flanking nucleotides participate in determining receptor specificity. May be required for brain development. May be involved in the regulation of retinal development (By similarity).


Liu, H.K., et al. Genes Dev. 24(7):683-695(2010)
Iwahara, N., et al. Biochem. Biophys. Res. Commun. 386(4):671-675(2009)
de Krom, M., et al. Biol. Psychiatry 65(7):625-630(2009)
Kumar, R.A., et al. Am. J. Med. Genet. B Neuropsychiatr. Genet. 147B (6), 880-889 (2008) :
Yokoyama, A., et al. Mol. Cell. Biol. 28(12):3995-4003(2008)

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$ 80.00
$ 99.00
Cat# BP19904c
(40 western blots)
Availability: 2 weeks
Bulk Size
Seasonal Special on Bulk Order
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