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NR2E1 Blocking Peptide (Center)
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
| Primary Accession | Q9Y466 |
|---|---|
| Other Accession | P70052, Q64104, Q91379, NP_003260.1 |
| Gene ID | 7101 |
|---|---|
| Other Names | Nuclear receptor subfamily 2 group E member 1, Nuclear receptor TLX, Protein tailless homolog, Tll, hTll, NR2E1, TLX |
| Target/Specificity | The synthetic peptide sequence is selected from aa 90-102 of HUMAN NR2E1 |
| Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
| Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
| Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
| Name | NR2E1 |
|---|---|
| Synonyms | TLX |
| Function | Orphan receptor that binds DNA as a monomer to hormone response elements (HRE) containing an extended core motif half-site sequence 5'-AAGGTCA-3' in which the 5' flanking nucleotides participate in determining receptor specificity (By similarity). May be required to pattern anterior brain differentiation. Involved in the regulation of retinal development and essential for vision. During retinogenesis, regulates PTEN-Cyclin D expression via binding to the promoter region of PTEN and suppressing its activity (By similarity). May be involved in retinoic acid receptor (RAR) regulation in retinal cells. |
| Cellular Location | Nucleus {ECO:0000255|PROSITE-ProRule:PRU00407}. |
| Tissue Location | Brain specific. Present in all brain sections tested, highest levels in the caudate nucleus and hippocampus, weakest levels in the thalamus. |
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
Background
Orphan receptor that binds DNA as a monomer to hormone response elements (HRE) containing an extended core motif half-site sequence 5'-AAGGTCA-3' in which the 5' flanking nucleotides participate in determining receptor specificity. May be required for brain development. May be involved in the regulation of retinal development (By similarity).
References
Liu, H.K., et al. Genes Dev. 24(7):683-695(2010)
Iwahara, N., et al. Biochem. Biophys. Res. Commun. 386(4):671-675(2009)
de Krom, M., et al. Biol. Psychiatry 65(7):625-630(2009)
Kumar, R.A., et al. Am. J. Med. Genet. B Neuropsychiatr. Genet. 147B (6), 880-889 (2008) :
Yokoyama, A., et al. Mol. Cell. Biol. 28(12):3995-4003(2008)
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