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FAM49B Blocking Peptide (N-term)
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
| Primary Accession | Q9NUQ9 |
|---|---|
| Other Accession | Q921M7, Q2KJI3, NP_057707.3 |
| Gene ID | 51571 |
|---|---|
| Other Names | Protein FAM49B, L1, FAM49B |
| Target/Specificity | The synthetic peptide sequence is selected from aa 22-36 of HUMAN FAM49B |
| Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
| Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
| Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
| Name | CYRIB {ECO:0000303|PubMed:30250061, ECO:0000312|HGNC:HGNC:25216} |
|---|---|
| Function | Negatively regulates RAC1 signaling and RAC1-driven cytoskeletal remodeling (PubMed:31285585, PubMed:30250061). Regulates chemotaxis, cell migration and epithelial polarization by controlling the polarity, plasticity, duration and extent of protrusions. Limits Rac1 mediated activation of the Scar/WAVE complex, focuses protrusion signals and regulates pseudopod complexity by inhibiting Scar/WAVE- induced actin polymerization (PubMed:30250061). Protects against Salmonella bacterial infection. Attenuates processes such as macropinocytosis, phagocytosis and cell migration and restrict sopE- mediated bacterial entry (PubMed:31285585). Restricts also infection mediated by Mycobacterium tuberculosis and Listeria monocytogenes (By similarity). Involved in the regulation of mitochondrial dynamics and oxidative stress (PubMed:29059164). |
| Cellular Location | Membrane; Lipid-anchor. Mitochondrion |
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Provided below are standard protocols that you may find useful for product applications.
Background
The function of this protein is unknown.
References
Melzer, D., et al. PLoS Genet. 4 (5), E1000072 (2008) :
Lamesch, P., et al. Genomics 89(3):307-315(2007)
Petroziello, J., et al. Oncogene 23(46):7734-7745(2004)
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