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RXFP1 Blocking Peptide (C-term)
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
| Primary Accession | Q9HBX9 |
|---|---|
| Other Accession | NP_067647.2 |
| Gene ID | 59350 |
|---|---|
| Other Names | Relaxin receptor 1, Leucine-rich repeat-containing G-protein coupled receptor 7, Relaxin family peptide receptor 1, RXFP1, LGR7 |
| Target/Specificity | The synthetic peptide sequence is selected from aa 700-713 of HUMAN RXFP1 |
| Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
| Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
| Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
| Name | RXFP1 |
|---|---|
| Synonyms | LGR7 |
| Function | Receptor for relaxins. The activity of this receptor is mediated by G proteins leading to stimulation of adenylate cyclase and an increase of cAMP. Binding of the ligand may also activate a tyrosine kinase pathway that inhibits the activity of a phosphodiesterase that degrades cAMP. |
| Cellular Location | Cell membrane; Multi-pass membrane protein |
| Tissue Location | Expressed in the brain, kidney, testis, placenta, uterus, ovary, adrenal, prostate, skin and heart. Not detected in spleen. |
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
Background
Receptor for relaxins. The activity of this receptor is mediated by G proteins leading to stimulation of adenylate cyclase and an increase of cAMP. Binding of the ligand may also activate a tyrosine kinase pathway that inhibits the activity of a phosphodiesterase that degrades cAMP.
References
Halls, M.L., et al. EMBO J. 29(16):2772-2787(2010)
Singh, S., et al. Mol. Cell. Endocrinol. 315 (1-2), 239-245 (2010) :
Talmud, P.J., et al. Am. J. Hum. Genet. 85(5):628-642(2009)
Feng, S., et al. Ann. N. Y. Acad. Sci. 1160, 379-380 (2009) :
Li, Z., et al. Ann. N. Y. Acad. Sci. 1160, 374-378 (2009) :
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