|Other Accession||Q60610, NP_003244.2|
|Other Names||T-lymphoma invasion and metastasis-inducing protein 1, TIAM-1, TIAM1|
|Target/Specificity||The synthetic peptide sequence is selected from aa 1493-1506 of HUMAN TIAM1|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Modulates the activity of RHO-like proteins and connects extracellular signals to cytoskeletal activities. Acts as a GDP- dissociation stimulator protein that stimulates the GDP-GTP exchange activity of RHO-like GTPases and activates them. Activates RAC1, CDC42, and to a lesser extent RHOA. Required for normal cell adhesion and cell migration.|
|Cellular Location||Cell junction. Cell membrane; Peripheral membrane protein; Cytoplasmic side. Note=Detected at the boundary between cells with actin-rich protrusions (By similarity) Presence of KRIT1, CDH5 and RAP1B is required for its localization to the cell junction.|
|Tissue Location||Found in virtually all analyzed tumor cell lines including B- and T-lymphomas, neuroblastomas, melanomas and carcinomas|
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Modulates the activity of RHO-like proteins and connects extracellular signals to cytoskeletal activities. Acts as a GDP-dissociation stimulator protein that stimulates the GDP-GTP exchange activity of RHO-like GTPases and activates them. Activates RAC1, CDC42, and to a lesser extent RHOA.
Yang, W., et al. Jpn. J. Clin. Oncol. 40(11):1053-1059(2010)
Moriarty, C.H., et al. J. Biol. Chem. 285(27):20541-20546(2010)
Rose, J.E., et al. Mol. Med. 16 (7-8), 247-253 (2010) :
Rajagopal, S., et al. J. Biol. Chem. 285(23):18060-18071(2010)
Shepherd, T.R., et al. J. Mol. Biol. 398(5):730-746(2010)
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