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TIAM1 Blocking Peptide (C-term)
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
| Primary Accession | Q13009 |
|---|---|
| Other Accession | Q60610, NP_003244.2 |
| Gene ID | 7074 |
|---|---|
| Other Names | T-lymphoma invasion and metastasis-inducing protein 1, TIAM-1, TIAM1 |
| Target/Specificity | The synthetic peptide sequence is selected from aa 1493-1506 of HUMAN TIAM1 |
| Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
| Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
| Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
| Name | TIAM1 {ECO:0000303|PubMed:7731688, ECO:0000312|HGNC:HGNC:11805} |
|---|---|
| Function | Guanyl-nucleotide exchange factor that activates RHO-like proteins and connects extracellular signals to cytoskeletal activities. Activates RAC1, CDC42, and to a lesser extent RHOA and their downstream signaling to regulate processes like cell adhesion and cell migration. |
| Cellular Location | Cell junction. Cell membrane; Peripheral membrane protein; Cytoplasmic side. Note=Detected at the boundary between cells with actin-rich protrusions (By similarity). Presence of KRIT1, CDH5 and RAP1B is required for its localization to the cell junction |
| Tissue Location | Found in virtually all analyzed tumor cell lines including B- and T-lymphomas, neuroblastomas, melanomas and carcinomas |
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
Background
Modulates the activity of RHO-like proteins and connects extracellular signals to cytoskeletal activities. Acts as a GDP-dissociation stimulator protein that stimulates the GDP-GTP exchange activity of RHO-like GTPases and activates them. Activates RAC1, CDC42, and to a lesser extent RHOA.
References
Yang, W., et al. Jpn. J. Clin. Oncol. 40(11):1053-1059(2010)
Moriarty, C.H., et al. J. Biol. Chem. 285(27):20541-20546(2010)
Rose, J.E., et al. Mol. Med. 16 (7-8), 247-253 (2010) :
Rajagopal, S., et al. J. Biol. Chem. 285(23):18060-18071(2010)
Shepherd, T.R., et al. J. Mol. Biol. 398(5):730-746(2010)
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