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ERF Blocking Peptide (C-term)
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
| Primary Accession | P50548 |
|---|---|
| Other Accession | NP_006485.2 |
| Gene ID | 2077 |
|---|---|
| Other Names | ETS domain-containing transcription factor ERF, Ets2 repressor factor, PE-2, ERF |
| Target/Specificity | The synthetic peptide sequence is selected from aa 500-514 of HUMAN ERF |
| Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
| Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
| Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
| Name | ERF |
|---|---|
| Function | Potent transcriptional repressor that binds to the H1 element of the Ets2 promoter. May regulate other genes involved in cellular proliferation. Required for extraembryonic ectoderm differentiation, ectoplacental cone cavity closure, and chorioallantoic attachment (By similarity). May be important for regulating trophoblast stem cell differentiation (By similarity). |
| Cellular Location | Nucleus. |
| Tissue Location | Highest levels in testis, ovary, pancreas, and heart. |
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Provided below are standard protocols that you may find useful for product applications.
Background
Members of the ETS family of transcription factors, such as ERF, regulate cell proliferation and differentiation. They share a highly conserved DNA-binding domain, the ETS domain, that recognizes the sequence GGAA/T (de Castro et al., 1997 [PubMed 9192842]). For further information on ETS transcription factors, see ETS1 (MIM 164720).
References
Verykokakis, M., et al. J. Biol. Chem. 282(41):30285-30294(2007)
Hester, K.D., et al. Cell Cycle 6(13):1594-1604(2007)
Olsen, J.V., et al. Cell 127(3):635-648(2006)
Beausoleil, S.A., et al. Nat. Biotechnol. 24(10):1285-1292(2006)
Grimwood, J., et al. Nature 428(6982):529-535(2004)
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