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POLK Blocking Peptide (Center)

Synthetic peptide

     
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Product Information
Primary Accession Q9UBT6
Other Accession NP_057302.1
Additional Information
Gene ID 51426
Other Names DNA polymerase kappa, DINB protein, DINP, POLK, DINB1
Target/Specificity The synthetic peptide sequence is selected from aa 546-560 of HUMAN POLK
Format Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name POLK
Synonyms DINB1
Function DNA polymerase specifically involved in DNA repair. Plays an important role in translesion synthesis, where the normal high-fidelity DNA polymerases cannot proceed and DNA synthesis stalls. Depending on the context, it inserts the correct base, but causes frequent base transitions, transversions and frameshifts. Lacks 3'-5' proofreading exonuclease activity. Forms a Schiff base with 5'-deoxyribose phosphate at abasic sites, but does not have lyase activity.
Cellular Location Nucleus. Note=Detected throughout the nucleus and at replication foci
Tissue Location Detected at low levels in testis, spleen, prostate and ovary. Detected at very low levels in kidney, colon, brain, heart, liver, lung, placenta, pancreas and peripheral blood leukocytes.
Research Areas
Citations (0)

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Background

External and internal DNA-damaging agents continually threaten the integrity of genetic material in cells. Although a variety of repair mechanisms exist to remove the resulting lesions, some lesions escape repair and block the replication machinery. Members of the Y family of DNA polymerases, such as POLK, permit the continuity of the replication fork by allowing replication through such DNA lesions. Each Y family polymerase has a unique DNA-damage bypass and fidelity profile. POLK is specialized for the extension step of lesion bypass (summary by Lone et al., 2007 [PubMed 17317631]).

References

Rose, J.E., et al. Mol. Med. 16 (7-8), 247-253 (2010) :
Monsees, G.M., et al. Breast Cancer Res. Treat. (2010) In press :
Katafuchi, A., et al. Nucleic Acids Res. 38(3):859-867(2010)
Fukuda, H., et al. J. Biol. Chem. 284(38):25585-25592(2009)
Irimia, A., et al. J. Biol. Chem. 284(33):22467-22480(2009)

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$ 80.00
$ 99.00
Cat# BP19981c
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