|Other Names||Tau-tubulin kinase 1, Brain-derived tau kinase, TTBK1, BDTK, KIAA1855|
|Target/Specificity||The synthetic peptide sequence is selected from aa 682-695 of HUMAN TTBK1|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Serine/threonine kinase which is able to phosphorylate TAU on serine, threonine and tyrosine residues. Induces aggregation of TAU.|
|Tissue Location||Expressed in the brain, particularly in cortical and hippocampal neurons. Weakly expressed in spinal cord and testis. No expression in adipose tissue, bladder, cervix, colon, esophagus, heart, kidney, liver, lung, ovary, placenta, prostate, skeletal muscle, small intestine, spleen, testis, thymus, thyroid or trachea.|
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Provided below are standard protocols that you may find useful for product applications.
Serine/threonine kinase which is able to phosphorylate TAU on serine, threonine and tyrosine residues. Induces aggregation of TAU.
Vazquez-Higuera, J.L., et al. Neurobiol. Aging (2010) In press :
Sato, S., et al. J. Neurosci. 28(53):14511-14521(2008)
Ewing, R.M., et al. Mol. Syst. Biol. 3, 89 (2007) :
Mungall, A.J., et al. Nature 425(6960):805-811(2003)
Takahashi, M., et al. FEBS Lett. 372(1):59-64(1995)
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