|Other Names||G2/mitotic-specific cyclin-B2, Ccnb2, Cycb2|
|Target/Specificity||The synthetic peptide sequence is selected from aa 385-398 of MOUSE Ccnb2|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Essential for the control of the cell cycle at the G2/M (mitosis) transition.|
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Provided below are standard protocols that you may find useful for product applications.
Cyclin B2 is a member of the cyclin family, specifically the B-type cyclins. The B-type cyclins, B1 and B2, associate with p34cdc2 and are essential components of the cell cycle regulatory machinery. B1 and B2 differ in their subcellular localization. Cyclin B1 co-localizes with microtubules, whereas cyclin B2 is primarily associated with the Golgi region. Cyclin B2 also binds to transforming growth factor beta RII and thus cyclin B2/cdc2 may play a key role in transforming growth factor beta-mediated cell cycle control.
Risley, M.D., et al. Dev. Biol. 342(2):146-156(2010)
Wu, T., et al. J. Biol. Chem. 285(24):18291-18300(2010)
De Martino, I., et al. Cancer Res. 69(5):1844-1850(2009)
Kawaguchi, A., et al. Development 135(18):3113-3124(2008)
Fogel, J.L., et al. Dev. Dyn. 237(5):1359-1372(2008)
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