TTPA Blocking Peptide (Center)
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Primary Accession | P49638 |
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Other Accession | P41034, Q8BWP5, NP_000361.1 |
Gene ID | 7274 |
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Other Names | Alpha-tocopherol transfer protein, Alpha-TTP, TTPA, TPP1 |
Target/Specificity | The synthetic peptide sequence is selected from aa 97-108 of HUMAN TTPA |
Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
Name | TTPA |
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Synonyms | TPP1 |
Function | Binds alpha-tocopherol, enhances its transfer between separate membranes, and stimulates its release from liver cells (PubMed:7887897). Binds both phosphatidylinositol 3,4-bisphosphate and phosphatidylinositol 4,5-bisphosphate; the resulting conformation change is important for the release of the bound alpha-tocopherol (By similarity). |
Cellular Location | Cytoplasm. |
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Provided below are standard protocols that you may find useful for product applications.
Background
This gene encodes a soluble protein that binds alpha-trocopherol, a form of vitamin E, with high selectivity and affinity. This protein plays an important role in regulating vitamin E levels in the body by transporting vitamin E between membrane vesicles and facilitating the secretion of vitamin E from hepatocytes to circulating lipoproteins. Mutations in this gene cause hereditary vitamin E deficiency (ataxia with vitamin E deficiency, AVED) and retinitis pigmentosa.
References
Zhang, W.X., et al. Lipids 44(7):631-641(2009)
Wright, M.E., et al. Cancer Res. 69(4):1429-1438(2009)
Fusco, C., et al. J. Child Neurol. 23(11):1328-1330(2008)
Rotzoll, D.E., et al. Eur. J. Obstet. Gynecol. Reprod. Biol. 140(2):183-191(2008)
Kara, B., et al. Turk. J. Pediatr. 50(5):471-475(2008)
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