|Other Accession||P41034, Q8BWP5, NP_000361.1|
|Other Names||Alpha-tocopherol transfer protein, Alpha-TTP, TTPA, TPP1|
|Target/Specificity||The synthetic peptide sequence is selected from aa 97-108 of HUMAN TTPA|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Binds alpha-tocopherol, enhances its transfer between separate membranes, and stimulates its release from liver cells (PubMed:7887897). Binds both phosphatidylinol 3,4-bisphosphate and phosphatidylinol 4,5-bisphosphate; the resulting conformation change is important for the release of the bound alpha-tocopherol (By similarity).|
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Provided below are standard protocols that you may find useful for product applications.
This gene encodes a soluble protein that binds alpha-trocopherol, a form of vitamin E, with high selectivity and affinity. This protein plays an important role in regulating vitamin E levels in the body by transporting vitamin E between membrane vesicles and facilitating the secretion of vitamin E from hepatocytes to circulating lipoproteins. Mutations in this gene cause hereditary vitamin E deficiency (ataxia with vitamin E deficiency, AVED) and retinitis pigmentosa.
Zhang, W.X., et al. Lipids 44(7):631-641(2009)
Wright, M.E., et al. Cancer Res. 69(4):1429-1438(2009)
Fusco, C., et al. J. Child Neurol. 23(11):1328-1330(2008)
Rotzoll, D.E., et al. Eur. J. Obstet. Gynecol. Reprod. Biol. 140(2):183-191(2008)
Kara, B., et al. Turk. J. Pediatr. 50(5):471-475(2008)
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