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C1orf106 Blocking Peptide (Center)
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
| Primary Accession | Q3KP66 |
|---|---|
| Other Accession | Q7TN12, NP_060735.2 |
| Gene ID | 55765 |
|---|---|
| Other Names | Uncharacterized protein C1orf106, C1orf106 |
| Target/Specificity | The synthetic peptide sequence is selected from aa 328-341 of HUMAN C1orf106 |
| Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
| Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
| Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
| Name | INAVA (HGNC:25599) |
|---|---|
| Synonyms | C1orf106 |
| Function | Expressed in peripheral macrophages and intestinal myeloid- derived cells, is required for optimal PRR (pattern recognition receptor)-induced signaling, cytokine secretion, and bacterial clearance. Upon stimulation of a broad range of PRRs (pattern recognition receptor) such as NOD2 or TLR2, TLR3, TLR4, TLR5, TLR7 and TLR9, associates with YWHAQ/14-3-3T, which in turn leads to the recruitment and activation of MAP kinases and NF-kappa-B signaling complexes that amplifies PRR-induced downstream signals and cytokine secretion (PubMed:28436939). In the intestine, regulates adherens junction stability by regulating the degradation of CYTH1 and CYTH2, probably acting as substrate cofactor for SCF E3 ubiquitin-protein ligase complexes. Stabilizes adherens junctions by limiting CYTH1- dependent ARF6 activation (PubMed:29420262). |
| Cellular Location | Nucleus. Cytoplasm. Note=Translocates to the nucleus upon NOD2 stimulation. |
| Tissue Location | Highly expressed in intestinal myeloid-derived cells and expressed in monocyte-derived macrophages upon induction by PRR activation. |
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Provided below are standard protocols that you may find useful for product applications.
Background
The function of this protein is unknown.
References
Barrett, J.C., et al. Nat. Genet. 41(12):1330-1334(2009)
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