|Other Names||UPF0556 protein C19orf10, Interleukin-25, IL-25, Stromal cell-derived growth factor SF20, C19orf10, IL25|
|Target/Specificity||The synthetic peptide sequence is selected from aa 127-141 of HUMAN C19orf10|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Bone marrow-derived monocyte and paracrine-acting protein that promotes cardiac myocyte survival and adaptive angiogenesis for cardiac protection and/or repair after myocardial infarction (MI). Stimulates endothelial cell proliferation through a MAPK1/3-, STAT3- and CCND1-mediated signaling pathway. Inhibits cardiac myocyte apoptosis in a PI3K/AKT-dependent signaling pathway (By similarity). Involved in endothelial cell proliferation and angiogenesis (PubMed:25581518).|
|Cellular Location||Secreted. Endoplasmic reticulum-Golgi intermediate compartment Note=Secreted into blood plasma.|
|Tissue Location||Expressed in bone marrow cells (PubMed:25581518). Expressed in synovial tissue. Found in synovial fluid of patients with arthropaties (PubMed:17362502)|
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Provided below are standard protocols that you may find useful for product applications.
The protein encoded by this gene was previously thought to support proliferation of lymphoid cells and was considered an interleukin. However, this activity has not been reproducible and the function of this protein is currently unknown. [provided by RefSeq].
Weiler, T., et al. Arthritis Res. Ther. 9 (2), R30 (2007) :
Lim, J., et al. Cell 125(4):801-814(2006)
Grimwood, J., et al. Nature 428(6982):529-535(2004)
Buning, C., et al. Eur. J. Immunogenet. 30(5):329-333(2003)
Hurst, S.D., et al. J. Immunol. 169(1):443-453(2002)
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