|Other Accession||Q5XI81, Q61584, O70523, Q2TBT7, NP_005078.2|
|Other Names||Fragile X mental retardation syndrome-related protein 1, hFXR1p, FXR1|
|Target/Specificity||The synthetic peptide sequence is selected from aa 52-66 of HUMAN FXR1|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||RNA-binding protein required for embryonic and postnatal development of muscle tissue. May regulate intracellular transport and local translation of certain mRNAs (By similarity).|
|Tissue Location||Expressed in all tissues examined including heart, brain, kidney and testis.|
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Provided below are standard protocols that you may find useful for product applications.
The protein encoded by this gene is an RNA binding protein that interacts with the functionally-similar proteins FMR1 and FXR2. These proteins shuttle between the nucleus and cytoplasm and associate with polyribosomes, predominantly with the 60S ribosomal subunit. Three transcript variants encoding different isoforms have been found for this gene.
Coffee, R.L. Jr., et al. Dis Model Mech 3 (7-8), 471-485 (2010) :
Darnell, J.C., et al. Hum. Mol. Genet. 18(17):3164-3177(2009)
Purcell, S.M., et al. Nature 460(7256):748-752(2009)
Davidovic, L., et al. J. Med. Genet. 45(10):679-685(2008)
Vasudevan, S., et al. Cell 128(6):1105-1118(2007)
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