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UBR1 Blocking Peptide (N-term)

Synthetic peptide

Product Information
Primary Accession Q8IWV7
Other Accession O70481, NP_777576.1
Additional Information
Gene ID 197131
Other Names E3 ubiquitin-protein ligase UBR1, 632-, N-recognin-1, Ubiquitin-protein ligase E3-alpha-1, Ubiquitin-protein ligase E3-alpha-I, UBR1
Target/Specificity The synthetic peptide sequence is selected from aa 260-274 of HUMAN UBR1
Format Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name UBR1
Function E3 ubiquitin-protein ligase which is a component of the N-end rule pathway. Recognizes and binds to proteins bearing specific N-terminal residues that are destabilizing according to the N-end rule, leading to their ubiquitination and subsequent degradation. May be involved in pancreatic homeostasis. Binds leucine and is a negative regulator of the leucine-mTOR signaling pathway, thereby controlling cell growth.
Cellular Location Cytoplasm, cytosol
Tissue Location Broadly expressed, with highest levels in skeletal muscle, kidney and pancreas. Present in acinar cells of the pancreas (at protein level).
Research Areas
Citations (0)

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The N-end rule pathway is one proteolytic pathway of the ubiquitin system. The recognition component of this pathway, encoded by this gene, binds to a destabilizing N-terminal residue of a substrate protein and participates in the formation of a substrate-linked multiubiquitin chain. This leads to the eventual degradation of the substrate protein. The protein described in this record has a RING-type zinc finger and a UBR-type zinc finger. Mutations in this gene have been associated with Johanson-Blizzard syndrome.


Elting, M., et al. Am. J. Med. Genet. A 146A (23), 3058-3061 (2008) :
Alkhouri, N., et al. World J. Gastroenterol. 14(44):6863-6866(2008)
Yamaguchi, Y., et al. BMC Med. Genet. 9, 22 (2008) :
Schmidt, R.L., et al. Cancer Res. 67(24):11798-11810(2007)
Wei, S., et al. Mol. Pharmacol. 72(3):725-733(2007)

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$ 80.00
$ 99.00
Cat# BP20192a
(40 western blots)
Availability: 2 weeks
Bulk Size
Seasonal Special on Bulk Order
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