|Other Names||Protein atonal homolog 1, Class A basic helix-loop-helix protein 14, bHLHa14, Helix-loop-helix protein hATH-1, hATH1, ATOH1, ATH1, BHLHA14|
|Target/Specificity||The synthetic peptide sequence is selected from aa 325-338 of HUMAN ATOH1|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Transcriptional regulator. Activates E box-dependent transcription in collaboration with TCF3/E47, but the activity is completely antagonized by the negative regulator of neurogenesis HES1. Plays a role in the differentiation of subsets of neural cells by activating E box-dependent transcription (By similarity).|
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Provided below are standard protocols that you may find useful for product applications.
This protein belongs to the basic helix-loop-helix (BHLH) family of transcription factors. It activates E-box dependent transcription along with E47.
Kazanjian, A., et al. Gastroenterology 139(3):918-928(2010)
Heiskala, K., et al. Histol. Histopathol. 25(1):63-72(2010)
Maricich, S.M., et al. J. Neurosci. 29(36):11123-11133(2009)
Bossuyt, W., et al. PLoS Biol. 7 (2), E39 (2009) :
Aragaki, M., et al. Biochem. Biophys. Res. Commun. 368(4):923-929(2008)
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