Mouse Ublcp1 Blocking Peptide (Center)
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Primary Accession | Q8BGR9 |
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Other Accession | NP_077795.2 |
Gene ID | 79560 |
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Other Names | Ubiquitin-like domain-containing CTD phosphatase 1, Nuclear proteasome inhibitor UBLCP1, Ublcp1 |
Target/Specificity | The synthetic peptide sequence is selected from aa 117-128 of MOUSE Ublcp1 |
Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
Name | Ublcp1 |
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Function | Dephosphorylates 26S nuclear proteasomes, thereby decreasing their proteolytic activity. Recruited to the 19S regulatory particle of the 26S proteasome through its interaction with 19S component PSMD2/RPN1. Once recruited, dephosphorylates 19S component PSMC2/RPT1 which impairs PSMC2 ATPase activity and disrupts 26S proteasome assembly. Has also been reported to stimulate the proteolytic activity of the 26S proteasome. |
Cellular Location | Nucleus {ECO:0000250|UniProtKB:Q8WVY7}. Note=Colocalizes with nuclear proteasomes {ECO:0000250|UniProtKB:Q8WVY7} |
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Provided below are standard protocols that you may find useful for product applications.
Background
May specifically dephosphorylate 'Ser-5' of the heptad repeats YSPTSPS in the C-terminal domain of the largest RNA polymerase II subunit (By similarity).
References
Zambrowicz, B.P., et al. Proc. Natl. Acad. Sci. U.S.A. 100(24):14109-14114(2003)
Sasaki, N., et al. Genomics 49(2):167-179(1998)
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