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MEX3C Blocking Peptide (C-term)

Synthetic peptide

Product Information
Primary Accession Q5U5Q3
Other Accession Q05A36, NP_057710.3
Additional Information
Gene ID 51320
Other Names RNA-binding E3 ubiquitin-protein ligase MEX3C, 632-, RING finger and KH domain-containing protein 2, RING finger protein 194, MEX3C, RKHD2, RNF194
Target/Specificity The synthetic peptide sequence is selected from aa 551-564 of HUMAN MEX3C
Format Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name MEX3C
Synonyms RKHD2, RNF194
Function E3 ubiquitin ligase responsible for the post- transcriptional regulation of common HLA-A allotypes. Binds to the 3' UTR of HLA-A2 mRNA, and regulates its levels by promoting mRNA decay. RNA binding is sufficient to prevent translation, but ubiquitin ligase activity is required for mRNA degradation.
Cellular Location Cytoplasm. Nucleus. Note=Predominantly expressed in the cytoplasm and shuttles between the cytoplasm and the nucleus through the CRM1 export pathway. May act as suppressor of replication stress and chromosome missegregation
Tissue Location Highest levels found in fetal brain and testis. Also expressed in thymus, salivary gland and uterus Highly expressed in cells of the innate immune system, in particular activated NK cells. Week expression in the intestine
Research Areas
Citations (0)

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This gene encodes a member of a family of proteins with two K homology (KH) RNA-binding domains and a C-terminal RING-finger domain. The protein interacts with mRNA via the KH domains, and the protein shuttles between the nucleus and cytoplasm. Polymorphisms in this gene may contribute to hypertension.


Rose, J.E., et al. Mol. Med. 16 (7-8), 247-253 (2010) :
Buchet-Poyau, K., et al. Nucleic Acids Res. 35(4):1289-1300(2007)
Guzman, B., et al. Hypertension 48(5):883-891(2006)
Nusbaum, C., et al. Nature 437(7058):551-555(2005)

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$ 80.00
$ 99.00
Cat# BP20253b
(40 western blots)
Availability: 2 weeks
Bulk Size
Seasonal Special on Bulk Order
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