|Other Accession||Q4R8V9, NP_079359.2|
|Other Names||Enhancer of mRNA-decapping protein 3, LSM16 homolog, YjeF N-terminal domain-containing protein 2, YjeF_N2, hYjeF_N2, YjeF domain-containing protein 1, EDC3, LSM16, YJDC, YJEFN2|
|Target/Specificity||The synthetic peptide sequence is selected from aa 234-247 of HUMAN EDC3|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Synonyms||LSM16, YJDC, YJEFN2|
|Function||Binds single-stranded RNA. Involved in the process of mRNA degradation and in the positive regulation of mRNA decapping. May play a role in spermiogenesis and oogenesis.|
|Cellular Location||Cytoplasm, P-body. Note=Processing bodies (PB)|
|Tissue Location||Expressed in theca and granulosa cells in ovary, and in spermatids of the meiotic division part II and apical membrane of Sertoli cells in testis (at protein level) Also expressed in brain and mammary gland|
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Provided below are standard protocols that you may find useful for product applications.
EDC3 is associated with an mRNA-decapping complex required for removal of the 5-prime cap from mRNA prior to its degradation from the 5-prime end (Fenger-Gron et al., 2005 [PubMed 16364915]).
Tritschler, F., et al. Mol. Cell 33(5):661-668(2009)
Ling, S.H., et al. Mol. Cell. Biol. 28(19):5965-5976(2008)
Tritschler, F., et al. Mol. Cell. Biol. 27(24):8600-8611(2007)
Sugiyama, N., et al. Mol. Cell Proteomics 6(6):1103-1109(2007)
Rudolph, C., et al. Horm. Metab. Res. 39(5):322-335(2007)
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