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>   home   >   Products   >   Peptides   >   Blocking Peptides   >   VEGFD (VEGF4) Antibody Blocking peptide   

VEGFD (VEGF4) Antibody Blocking peptide

Synthetic peptide

     
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Product Information
Primary Accession O43915
Clone Names 2040505
Additional Information
Gene ID 2277
Other Names Vascular endothelial growth factor D, VEGF-D, c-Fos-induced growth factor, FIGF, FIGF, VEGFD
Target/Specificity The synthetic peptide sequence used to generate the antibody AP2043a was selected from the region of human VEGF4. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.
Format The synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml deionized water for a final concentration of 1 mg/ml.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name FIGF
Synonyms VEGFD
Function Growth factor active in angiogenesis, lymphangiogenesis and endothelial cell growth, stimulating their proliferation and migration and also has effects on the permeability of blood vessels. May function in the formation of the venous and lymphatic vascular systems during embryogenesis, and also in the maintenance of differentiated lymphatic endothelium in adults. Binds and activates VEGFR-2 (KDR/FLK1) and VEGFR-3 (FLT4) receptors.
Cellular Location Secreted.
Tissue Location Highly expressed in lung, heart, small intestine and fetal lung, and at lower levels in skeletal muscle, colon, and pancreas
Research Areas
Citations (0)

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Background

Vascular endothelial growth factors (VEGFs) are a family of secreted glycoproteins which act as mitogens primarily for vascular endothelial cells. VEGF-C (VEGF3) and VEGF-D (VEGF4) are recently identified members which share the conserved VEGF Homology Domain. They both have long N- and C-terminal propeptide extensions, and undergo proteolytic processing. Both VEGF-C and VEGF-D are widely expressed with highest expression in lymphnodes. The receptors VEGFR2 and VEGFR3 are expressed in vascular endothelial cells and lymphatic endothelial cells. VEGF-C and VEGFR3 are usually co-expressed at growing lymphatic endothelial cells. The VEGF-C/VEGFR3 signaling pathway has been shown to be crucial for lymphatic development. Recently increased expression of VEGF-C has been linked to a variety of human tumors and correlates with increased lymphatic density and lymph node metastasis.

References

McColl, B.K., et al., J. Exp. Med. 198(6):863-868 (2003).Rissanen, T.T., et al., Circ. Res. 92(10):1098-1106 (2003).Nakamura, Y., et al., Clin. Cancer Res. 9(2):716-721 (2003).Yokoyama, Y., et al., Br. J. Cancer 88(2):237-244 (2003).Funaki, H., et al., Oncology 64(4):416-422 (2003).

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$ 80.00
Cat# BP2043a
Size:
Quantity:
(40 western blots)
Availability: In Stock
Bulk Size
Seasonal Special on Bulk Order
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