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>   home   >   Products   >   Peptides   >   Blocking Peptides   >   p100 Antibody Blocking Peptide   

p100 Antibody Blocking Peptide

Synthetic peptide

Product Information
Primary Accession Q9ULW0
Clone Names 2011810
Peptide ID 2011810
Additional Information
Gene ID 22974
Other Names Targeting protein for Xklp2, Differentially expressed in cancerous and non-cancerous lung cells 2, DIL-2, Hepatocellular carcinoma-associated antigen 519, Hepatocellular carcinoma-associated antigen 90, Protein fls353, Restricted expression proliferation-associated protein 100, p100, TPX2, C20orf1, C20orf2, DIL2, HCA519
Target/Specificity The synthetic peptide sequences used to generate the antibody AP2044a was selected from the C-terminal region with phenylalanine at position 624, C-terminal region with serine at position 729, and center region of human p100. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.
Format The synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml deionized water for a final concentration of 1 mg/ml.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name TPX2
Synonyms C20orf1, C20orf2, DIL2, HCA519
Function Spindle assembly factor. Required for normal assembly of mitotic spindles. Required for normal assembly of microtubules during apoptosis. Required for chromatin and/or kinetochore dependent microtubule nucleation. Mediates AURKA localization to spindle microtubules. Activates AURKA by promoting its autophosphorylation at 'Thr-288' and protects this residue against dephosphorylation.
Cellular Location Nucleus. Cytoplasm, cytoskeleton, spindle. Cytoplasm, cytoskeleton, spindle pole. Note=During mitosis it is strictly associated with the spindle pole and with the mitotic spindle, whereas during S and G2, it is diffusely distributed throughout the nucleus. Is released from the nucleus in apoptotic cells and is detected on apoptotic microtubules
Tissue Location Expressed in lung carcinoma cell lines but not in normal lung tissues
Research Areas
Citations (0)

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The nuclear protein p100 is a proliferation-associated protein whose expression is restricted to cell cycle phases S, G2, and M. Exclusively expressed in proliferating cells from the transition G1/S until the end of cytokinesis. During mitosis it is strictly associated with the spindle pole and with the mitotic spindle, whereas during S and G2, it is diffusely distributed throughout the nucleus. The full-length cDNA encodes a 747-amino acid protein with a putative ATP/GTP-binding site motif. RT-PCR analysis demonstrated strong expression of in lung carcinoma cell lines but not in normal lung tissues. Expression was also found in adult placenta, skeletal muscle, thymus, testis, and small intestine and in fetal brain, liver, and kidney. P100 is also correlated to cancer prognosis.


Ota, T., et al., Nat. Genet. 36(1):40-45 (2004).Heidebrecht, H.J., et al., Mol. Cancer Res. 1(4):271-279 (2003).Garrett, S., et al., Curr. Biol. 12(23):2055-2059 (2002).Gruss, O.J., et al., Nat. Cell Biol. 4(11):871-879 (2002).Kufer, T.A., et al., J. Cell Biol. 158(4):617-623 (2002).

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$ 80.00
Cat# BP2044a
(40 western blots)
Availability: In Stock
Bulk Size
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