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NTN1 Blocking Peptide (C-term)

Synthetic peptide

     
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Product Information
Primary Accession O95631
Other Accession Q2HXW4, O09118, Q90922
Additional Information
Gene ID 9423
Other Names Netrin-1, Epididymis tissue protein Li 131P, NTN1, NTN1L
Target/Specificity The synthetic peptide sequence is selected from aa 583-596 of Human NTN1
Format Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name NTN1
Synonyms NTN1L
Function Netrins control guidance of CNS commissural axons and peripheral motor axons. Its association with either DCC or some UNC5 receptors will lead to axon attraction or repulsion, respectively. It also serve as a survival factor via its association with its receptors which prevent the initiation of apoptosis. Involved in tumorigenesis by regulating apoptosis.
Cellular Location Secreted, extracellular space, extracellular matrix
Tissue Location Widely expressed in normal adult tissues with highest levels in heart, small intestine, colon, liver and prostate. Reduced expression in brain tumors and neuroblastomas Expressed in epididymis (at protein level)
Research Areas
Citations (0)

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Background

Netrins control guidance of CNS commissural axons and peripheral motor axons. Its association with either DCC or some UNC5 receptors will lead to axon attraction or repulsion, respectively. It also serve as a survival factor via its association with its receptors which prevent the initiation of apoptosis. Involved in tumorigenesis by regulating apoptosis.

References

Meyerhardt J.A., et al. Cell Growth Differ. 10:35-42(1999).
Zody M.C., et al. Nature 440:1045-1049(2006).
Li J., et al. Mol. Cell. Proteomics 9:2517-2528(2010).
Mazelin L., et al. Nature 431:80-84(2004).
Liu G., et al. Proc. Natl. Acad. Sci. U.S.A. 106:2951-2956(2009).

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$ 80.00
$ 99.00
Cat# BP20462b
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