|Other Names||Biogenesis of lysosome-related organelles complex 1 subunit 4, BLOC-1 subunit 4, Protein cappuccino homolog, BLOC1S4, CNO|
|Target/Specificity||The synthetic peptide sequence is selected from aa 129-143 of Human BLOC1S4|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Component of the BLOC-1 complex, a complex that is required for normal biogenesis of lysosome-related organelles (LRO), such as platelet dense granules and melanosomes. In concert with the AP-3 complex, the BLOC-1 complex is required to target membrane protein cargos into vesicles assembled at cell bodies for delivery into neurites and nerve terminals. The BLOC-1 complex, in association with SNARE proteins, is also proposed to be involved in neurite extension. Plays a role in intracellular vesicle trafficking.|
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Provided below are standard protocols that you may find useful for product applications.
The BLOC-1 complex is required for normal biogenesis of lysosome-related organelles, such as platelet dense granules and melanosomes. Plays a role in intracellular vesicle trafficking (By similarity).
Ota T., et al. Nat. Genet. 36:40-45(2004).
Hillier L.W., et al. Nature 434:724-731(2005).
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