|Other Names||Ubiquitin carboxyl-terminal hydrolase 51, Deubiquitinating enzyme 51, Ubiquitin thioesterase 51, Ubiquitin-specific-processing protease 51, USP51|
|Target/Specificity||The synthetic peptide sequence is selected from aa 293-307 of Human USP51|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Specifically deubiquitinates 'Lys-14' (H2AK13Ub) and 'Lys-16'(H2AK15Ub) of histone H2A regulating the DNA damage response at double-strand breaks (DSBs) (PubMed:27083998). USP51 is recruited to chromatin after DNA damage and regulates the dynamic assembly/disassembly of TP53BP1 and BRCA1. Exhibits also activity for 'Lys-27' or 'Lys-63'-linked di-ubiquitin (PubMed:27083998).|
|Cellular Location||Chromosome. Note=Upon DNA damage, chromatin-bound USP51 disassociates from chromatin immediately following DNA damage and reassociates with chromatin following DNA repair.|
|Tissue Location||Expressed in prostate, brain, lung, aorta and kidney.|
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Provided below are standard protocols that you may find useful for product applications.
Quesada V., et al. Biochem. Biophys. Res. Commun. 314:54-62(2004).
Ross M.T., et al. Nature 434:325-337(2005).
Puente X.S., et al. Genome Res. 14:609-622(2004).
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