|Other Names||Transcriptional repressor scratch 1, Scratch homolog 1 zinc finger protein, SCRT, Scratch 1, hScrt, SCRT1|
|Target/Specificity||The synthetic peptide sequence used to generate the antibody AP2052a was selected from the C-term region of human SCRATCH1 . A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.|
|Format||The synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml deionized water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Transcriptional repressor that binds E-box motif CAGGTG. Can modulate the action of basic helix-loop-helix (bHLH) transcription factors, critical for neuronal differentiation.|
|Tissue Location||Brain specific..|
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Human SCRT cDNA encodes a protein of 348 amino acids expressed predominantly in the brain and spinal cord, but also in retina and in neuroendocrine cells of the lung. SCRT expression by RT-PCR is observed in lung cancers with neuroendocrine features. This protein holds in common with other Snail family members the ability to bind to E-box enhancer motifs, which are targets of basic helix-loop-helix (bHLH) transcription factors. SCRT impairs heterodimeric proneural bHLH protein achaete-scute homolog-1 and E12, leading to active transcriptional repression at E-box motifs. SCRT has been postulated to function in newly differentiating, postmitotic neurons and in cancers with neuroendocrine features by modulating the action of bHLH transcription factors pivotal to neuronal differentiation.
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