|Other Names||Zinc finger protein SNAI1, Protein snail homolog 1, Protein sna, SNAI1, SNAH|
|Target/Specificity||The synthetic peptide sequence used to generate the antibody AP2054a was selected from the N-term region of human SNAI1 . A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.|
|Format||The synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml deionized water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Involved in induction of the epithelial to mesenchymal transition (EMT), formation and maintenance of embryonic mesoderm, growth arrest, survival and cell migration. Binds to 3 E-boxes of the E-cadherin/CDH1 gene promoter and to the promoters of CLDN7 and KRT8 and, in association with histone demethylase KDM1A which it recruits to the promoters, causes a decrease in dimethylated H3K4 levels and represses transcription. Associates with EGR1 and SP1 to mediate tetradecanoyl phorbol acetate (TPA)-induced up- regulation of CDKN2B, possibly by binding to the CDKN2B promoter region 5'-TCACA-3. In addition, may also activate the CDKN2B promoter by itself.|
|Cellular Location||Nucleus. Cytoplasm. Note=Once phosphorylated (probably on Ser-107, Ser-111, Ser-115 and Ser-119) it is exported from the nucleus to the cytoplasm where subsequent phosphorylation of the destruction motif and ubiquitination involving BTRC occurs|
|Tissue Location||Expressed in a variety of tissues with the highest expression in kidney. Expressed in mesenchymal and epithelial cell lines.|
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Provided below are standard protocols that you may find useful for product applications.
The Drosophila embryonic protein snail is a zinc finger transcriptional repressor which downregulates the expression of ectodermal genes within the mesoderm. The nuclear protein encoded by this gene is structurally similar to the Drosophila snail protein, and is also thought to be critical for mesoderm formation in the developing embryo. At least two variants of a similar processed pseudogene have been found on chromosome 2.
Imai, T., et al., Am. J. Pathol. 163(4):1437-1447 (2003).Yokoyama, K., et al., Int. J. Oncol. 22(4):891-898 (2003).Guaita, S., et al., J. Biol. Chem. 277(42):39209-39216 (2002).Blanco, M.J., et al., Oncogene 21(20):3241-3246 (2002).Okubo, T., et al., Cancer Res. 61(4):1338-1346 (2001).
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