PLAUR Blocking Peptide (C-term)
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Primary Accession | Q03405 |
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Gene ID | 5329 |
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Other Names | Urokinase plasminogen activator surface receptor, U-PAR, uPAR, Monocyte activation antigen Mo3, CD87, PLAUR, MO3, UPAR |
Target/Specificity | The synthetic peptide sequence is selected from aa 293-305 of HUMAN PLAUR |
Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
Name | PLAUR |
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Synonyms | MO3, UPAR |
Function | Acts as a receptor for urokinase plasminogen activator. Plays a role in localizing and promoting plasmin formation. Mediates the proteolysis-independent signal transduction activation effects of U-PA. It is subject to negative-feedback regulation by U-PA which cleaves it into an inactive form. |
Cellular Location | Cell membrane. Cell projection, invadopodium membrane Note=Colocalized with FAP (seprase) preferentially at the cell surface of invadopodia membrane in a cytoskeleton-, integrin- and vitronectin- dependent manner. [Isoform 2]: Secreted {ECO:0000250|UniProtKB:P49616} |
Tissue Location | Expressed in neurons of the rolandic area of the brain (at protein level). Expressed in the brain |
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Provided below are standard protocols that you may find useful for product applications.
Background
Acts as a receptor for urokinase plasminogen activator. Plays a role in localizing and promoting plasmin formation. Mediates the proteolysis-independent signal transduction activation effects of U-PA. It is subject to negative-feedback regulation by U-PA which cleaves it into an inactive form.
References
Roldan A.L.,et al.EMBO J. 9:467-474(1990).
Min H.Y.,et al.J. Immunol. 148:3636-3642(1992).
Bayraktutan U.,et al.Biochem. Soc. Trans. 21:395-395(1993).
Pyke C.,et al.FEBS Lett. 326:69-74(1993).
Casey J.R.,et al.Blood 84:1151-1156(1994).
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