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CHRNA9 Blocking Peptide (N-term)

Synthetic peptide

     
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Product Information
Primary Accession Q9UGM1
Additional Information
Gene ID 55584
Other Names Neuronal acetylcholine receptor subunit alpha-9, Nicotinic acetylcholine receptor subunit alpha-9, NACHR alpha-9, CHRNA9, NACHRA9
Target/Specificity The synthetic peptide sequence is selected from aa 28-42 of HUMAN CHRNA9
Format Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name CHRNA9
Synonyms NACHRA9
Function Ionotropic receptor with a probable role in the modulation of auditory stimuli. Agonist binding induces a conformation change that leads to the opening of an ion-conducting channel across the plasma membrane (PubMed:11752216, PubMed:25282151). The channel is permeable to a range of divalent cations including calcium, the influx of which may activate a potassium current which hyperpolarizes the cell membrane (PubMed:11752216, PubMed:25282151). In the ear, this may lead to a reduction in basilar membrane motion, altering the activity of auditory nerve fibers and reducing the range of dynamic hearing. This may protect against acoustic trauma. May also regulate keratinocyte adhesion (PubMed:11021840).
Cellular Location Cell junction, synapse, postsynaptic cell membrane; Multi-pass membrane protein Cell membrane; Multi-pass membrane protein
Tissue Location Expressed in cochlea, keratinocytes, pituitary gland, B-cells and T-cells.
Research Areas
Citations (0)

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Background

Ionotropic receptor with a probable role in the modulation of auditory stimuli. Agonist binding may induce an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane. The channel is permeable to a range of divalent cations including calcium, the influx of which may activate a potassium current which hyperpolarizes the cell membrane. In the ear, this may lead to a reduction in basilar membrane motion, altering the activity of auditory nerve fibers and reducing the range of dynamic hearing. This may protect against acoustic trauma. May also regulate keratinocyte adhesion.

References

Sgard F.,et al.Mol. Pharmacol. 61:150-159(2002).
Lustig L.R.,et al.Cytogenet. Genome Res. 98:154-159(2002).
Hillier L.W.,et al.Nature 434:724-731(2005).
Nguyen V.T.,et al.Am. J. Pathol. 157:1377-1391(2000).
Peng H.,et al.Life Sci. 76:263-280(2004).

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$ 80.00
Cat# BP20598a
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