|Other Names||Bone morphogenetic protein 3B, BMP-3B, Bone-inducing protein, BIP, Growth/differentiation factor 10, GDF-10, GDF10, BMP3B|
|Target/Specificity||The synthetic peptide sequence used to generate the antibody AP2060a was selected from the N-term region of human GDF10 . A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.|
|Format||The synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml deionized water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Tissue Location||Expressed in femur, brain, lung, skeletal muscle, pancreas and testis.|
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Provided below are standard protocols that you may find useful for product applications.
GDF10 is a member of the bone morphogenetic protein (BMP) family and the TGF-beta superfamily. This group of proteins is characterized by a polybasic proteolytic processing site which is cleaved to produce a mature protein containing seven conserved cysteine residues. The members of this family are regulators of cell growth and differentiation in both embryonic and adult tissues. Studies in mice suggest that the protein encoded by this gene plays a role in skeletal morphogenesis.
Ducy, P., et al., Kidney Int. 57(6):2207-2214 (2000).Hino, J., et al., Biochem. Biophys. Res. Commun. 223(2):304-310 (1996).Cunningham, N.S., et al., Growth Factors 12(2):99-109 (1995).
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