|Other Names||Growth/differentiation factor 11, GDF-11, Bone morphogenetic protein 11, BMP-11, GDF11, BMP11|
|Target/Specificity||The synthetic peptide sequence used to generate the antibody AP2061a was selected from the N-term region of human GDF11 . A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.|
|Format||The synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml deionized water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Secreted signal that acts globally to specify positional identity along the anterior/posterior axis during development. Play critical roles in patterning both mesodermal and neural tissues and in establishing the skeletal pattern.|
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Provided below are standard protocols that you may find useful for product applications.
GDF11 is a member of the bone morphogenetic protein (BMP) family and the TGF-beta superfamily. This group of proteins is characterized by a polybasic proteolytic processing site which is cleaved to produce a mature protein containing seven conserved cysteine residues. The members of this family are regulators of cell growth and differentiation in both embryonic and adult tissues. Studies in mice and Xenopus suggest that this protein is involved in mesodermal formation and neurogenesis during embryonic development.
Lee, S.J., et al., Curr. Opin. Genet. Dev. 9(5):604-607 (1999).McPherron, A.C., et al., Nat. Genet. 22(3):260-264 (1999).Gamer, L.W., et al., Dev. Biol. 208(1):222-232 (1999).Hillier, L.D., et al., Genome Res. 6(9):807-828 (1996).
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