|Other Accession||A5GFS8, A2VDZ9|
|Other Names||Vesicle-associated membrane protein-associated protein B/C, VAMP-B/VAMP-C, VAMP-associated protein B/C, VAP-B/VAP-C, VAPB|
|Target/Specificity||The synthetic peptide sequence is selected from aa 126-159 of HUMAN VAPB|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Participates in the endoplasmic reticulum unfolded protein response (UPR) by inducing ERN1/IRE1 activity. Involved in cellular calcium homeostasis regulation.|
|Cellular Location||Endoplasmic reticulum membrane; Single-pass type IV membrane protein Note=Present in mitochondria-associated membranes that are endoplasmic reticulum membrane regions closely apposed to the outer mitochondrial membrane.|
|Tissue Location||Ubiquitous. Isoform 1 predominates.|
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Participates in the endoplasmic reticulum unfolded protein response (UPR) by inducing ERN1/IRE1 activity. Involved in cellular calcium homeostasis regulation.
Nishimura Y.,et al.Biochem. Biophys. Res. Commun. 254:21-26(1999).
Hu R.-M.,et al.Proc. Natl. Acad. Sci. U.S.A. 97:9543-9548(2000).
Clark H.F.,et al.Genome Res. 13:2265-2270(2003).
Deloukas P.,et al.Nature 414:865-871(2001).
Gevaert K.,et al.Nat. Biotechnol. 21:566-569(2003).
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