|Other Names||Growth/differentiation factor 15, GDF-15, Macrophage inhibitory cytokine 1, MIC-1, NSAID-activated gene 1 protein, NAG-1, NSAID-regulated gene 1 protein, NRG-1, Placental TGF-beta, Placental bone morphogenetic protein, Prostate differentiation factor, GDF15, MIC1, PDF, PLAB, PTGFB|
|Target/Specificity||The synthetic peptide sequence used to generate the antibody AP2062a was selected from the N-term region of human GDF15 . A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.|
|Format||The synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml deionized water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Synonyms||MIC1, PDF, PLAB, PTGFB|
|Tissue Location||Highly expressed in placenta, with lower levels in prostate and colon and some expression in kidney|
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Provided below are standard protocols that you may find useful for product applications.
GDF15 is a member of the bone morphogenetic protein (BMP) family and the TGF-beta superfamily. This group of proteins is characterized by a polybasic proteolytic processing site which is cleaved to produce a mature protein containing seven conserved cysteine residues. The members of this family are regulators of cell growth and differentiation in both embryonic and adult tissues. GDF15 is highly expressed in placenta, with lower levels in prostate and colon and some expression in kidney.
Paralkar, V.M., et al., J. Biol. Chem. 273(22):13760-13767 (1998).Yokoyama-Kobayashi, M., et al., J. Biochem. 122(3):622-626 (1997).Hromas, R., et al., Biochim. Biophys. Acta 1354(1):40-44 (1997).Bootcov, M.R., et al., Proc. Natl. Acad. Sci. U.S.A. 94(21):11514-11519 (1997).Lawton, L.N., et al., Gene 203(1):17-26 (1997).
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