|Other Names||Protein ELYS, Embryonic large molecule derived from yolk sac, Protein MEL-28, Putative AT-hook-containing transcription factor 1, AHCTF1, ELYS, TMBS62|
|Target/Specificity||The synthetic peptide sequence is selected from aa 1210-1240 of HUMAN AHCTF1|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Required for the assembly of a functional nuclear pore complex (NPC) on the surface of chromosomes as nuclei form at the end of mitosis. May initiate NPC assembly by binding to chromatin and recruiting the Nup107-160 subcomplex of the NPC. Also required for the localization of the Nup107-160 subcomplex of the NPC to the kinetochore during mitosis and for the completion of cytokinesis.|
|Cellular Location||Cytoplasm. Nucleus matrix. Chromosome, centromere, kinetochore. Nucleus, nucleoplasm. Nucleus, nuclear pore complex. Note=Localizes to the nuclear pore complex (NPC) throughout interphase. Localizes to the kinetochore from prophase, and this appears to require the Nup107- 160 subcomplex of the NPC. Localizes to the periphery of chromatin from late anaphase|
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Required for the assembly of a functional nuclear pore complex (NPC) on the surface of chromosomes as nuclei form at the end of mitosis. May initiate NPC assembly by binding to chromatin and recruiting the Nup107-160 subcomplex of the NPC. Also required for the localization of the Nup107-160 subcomplex of the NPC to the kinetochore during mitosis and for the completion of cytokinesis.
Kimura N.,et al.Genes Cells 7:435-446(2002).
Lightfoot J.,et al.Submitted (OCT-2002) to the EMBL/GenBank/DDBJ databases.
Gregory S.G.,et al.Nature 441:315-321(2006).
Bechtel S.,et al.BMC Genomics 8:399-399(2007).
Liu B.,et al.Submitted (JUL-1999) to the EMBL/GenBank/DDBJ databases.
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