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Human-AHCTF1 (S1232) Blocking Peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
| Primary Accession | Q8WYP5 |
|---|
| Gene ID | 25909 |
|---|---|
| Other Names | Protein ELYS, Embryonic large molecule derived from yolk sac, Protein MEL-28, Putative AT-hook-containing transcription factor 1, AHCTF1, ELYS, TMBS62 |
| Target/Specificity | The synthetic peptide sequence is selected from aa 1210-1240 of HUMAN AHCTF1 |
| Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
| Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
| Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
| Name | AHCTF1 |
|---|---|
| Synonyms | ELYS, TMBS62 |
| Function | Required for the assembly of a functional nuclear pore complex (NPC) on the surface of chromosomes as nuclei form at the end of mitosis. May initiate NPC assembly by binding to chromatin and recruiting the Nup107-160 subcomplex of the NPC. Also required for the localization of the Nup107-160 subcomplex of the NPC to the kinetochore during mitosis and for the completion of cytokinesis. |
| Cellular Location | Cytoplasm {ECO:0000250|UniProtKB:Q8CJF7}. Nucleus. Nucleus envelope Nucleus matrix. Chromosome, centromere, kinetochore Nucleus, nucleoplasm. Nucleus, nuclear pore complex. Note=Localizes to the nuclear pore complex (NPC) throughout interphase. Localizes to the kinetochore from prophase, and this appears to require the Nup107-160 subcomplex of the NPC. Localizes to the periphery of chromatin from late anaphase. |
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Provided below are standard protocols that you may find useful for product applications.
Background
Required for the assembly of a functional nuclear pore complex (NPC) on the surface of chromosomes as nuclei form at the end of mitosis. May initiate NPC assembly by binding to chromatin and recruiting the Nup107-160 subcomplex of the NPC. Also required for the localization of the Nup107-160 subcomplex of the NPC to the kinetochore during mitosis and for the completion of cytokinesis.
References
Kimura N.,et al.Genes Cells 7:435-446(2002).
Lightfoot J.,et al.Submitted (OCT-2002) to the EMBL/GenBank/DDBJ databases.
Gregory S.G.,et al.Nature 441:315-321(2006).
Bechtel S.,et al.BMC Genomics 8:399-399(2007).
Liu B.,et al.Submitted (JUL-1999) to the EMBL/GenBank/DDBJ databases.
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