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FXYD1 Blocking Peptide (C-term)

Synthetic peptide

     
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Product Information
Primary Accession O00168
Other Accession O08589, Q9Z239, Q3SZX0
Additional Information
Gene ID 5348
Other Names Phospholemman, FXYD domain-containing ion transport regulator 1, FXYD1, PLM
Target/Specificity The synthetic peptide sequence is selected from aa 69-81 of HUMAN FXYD1
Format Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name FXYD1 (HGNC:4025)
Function Associates with and regulates the activity of the sodium/potassium-transporting ATPase (NKA) which transports Na(+) out of the cell and K(+) into the cell. Inhibits NKA activity in its unphosphorylated state and stimulates activity when phosphorylated. Reduces glutathionylation of the NKA beta-1 subunit ATP1B1, thus reversing glutathionylation-mediated inhibition of ATP1B1. Contributes to female sexual development by maintaining the excitability of neurons which secrete gonadotropin-releasing hormone.
Cellular Location Cell membrane, sarcolemma {ECO:0000250|UniProtKB:P56513}; Single-pass type I membrane protein. Apical cell membrane {ECO:0000250|UniProtKB:O08589}; Single-pass type I membrane protein. Membrane, caveola {ECO:0000250|UniProtKB:O08589}. Note=Detected in the apical cell membrane in brain. In myocytes, localizes to sarcolemma, t-tubules and intercalated disks. {ECO:0000250|UniProtKB:O08589}
Tissue Location Highest expression in skeletal muscle and heart. Moderate levels in brain, placenta, lung, liver, pancreas, uterus, bladder, prostate, small intestine and colon with mucosal lining. Very low levels in kidney, colon and small intestine without mucosa, prostate without endothelial lining, spleen, and testis.
Research Areas
Citations (0)

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Background

May have a functional role in muscle contraction. Induces a hyperpolarization-activated chloride current when exogenously expressed.

References

Chen L.-S.K.,et al.Genomics 41:435-443(1997).
Sweadner K.J.,et al.Genomics 68:41-56(2000).
Ota T.,et al.Nat. Genet. 36:40-45(2004).
Mounsey J.P.,et al.J. Biol. Chem. 275:23362-23367(2000).
Tulloch L.B.,et al.J. Biol. Chem. 286:36020-36031(2011).

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$ 80.00
Cat# BP20771c
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