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PRPF6 Blocking Peptide (N-term)

Synthetic peptide

     
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Product Information
Primary Accession O94906
Other Accession A1A5S1, Q91YR7, Q2KJJ0
Additional Information
Gene ID 24148
Other Names Pre-mRNA-processing factor 6, Androgen receptor N-terminal domain-transactivating protein 1, ANT-1, PRP6 homolog, U5 snRNP-associated 102 kDa protein, U5-102 kDa protein, PRPF6, C20orf14
Target/Specificity The synthetic peptide sequence is selected from aa 196-209 of HUMAN PRPF6
Format Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name PRPF6
Synonyms C20orf14
Function Involved in pre-mRNA splicing as component of the U4/U6- U5 tri-snRNP complex, one of the building blocks of the spliceosome. Enhances dihydrotestosterone-induced transactivation activity of AR, as well as dexamethasone-induced transactivation activity of NR3C1, but does not affect estrogen-induced transactivation.
Cellular Location Nucleus, nucleoplasm. Nucleus speckle. Note=Localized in splicing speckles
Tissue Location Widely expressed.
Research Areas
Citations (0)

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Background

Involved in pre-mRNA splicing as component of the U4/U6- U5 tri-snRNP complex, one of the building blocks of the spliceosome. Enhances dihydrotestosterone-induced transactivation activity of AR, as well as dexamethasone-induced transactivation activity of NR3C1, but does not affect estrogen-induced transactivation.

References

Nishikimi A.,et al.Biochim. Biophys. Acta 1435:147-152(1999).
Makarov E.M.,et al.J. Mol. Biol. 298:567-575(2000).
Yuryev A.,et al.Mol. Cell. Biol. 20:4870-4878(2000).
Ota T.,et al.Nat. Genet. 36:40-45(2004).
Deloukas P.,et al.Nature 414:865-871(2001).

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$ 80.00
$ 99.00
Cat# BP20777a
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